Publications for the metabolite (-)-Epicatechin 3'-O-glucuronide with food phytochemical (-)-Epicatechin

1. Actis-Goretta L, Leveques A, Giuffrida F, Romanov-Michailidis F, Viton F, Barron D, Duenas-Paton M, Gonzalez-Manzano S, Santos-Buelga C, Williamson G, Dionisi F: Elucidation of (-)-epicatechin metabolites after ingestion of chocolate by healthy humans. Free Radic Biol Med. 2012 Aug 15;53(4):787-95. doi: 10.1016/j.freeradbiomed.2012.05.023. Epub 2012 Jun 1. [PubMed:22664313 ]
2. Stalmach A, Troufflard S, Serafini M, Crozier A: Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans. Mol Nutr Food Res. 2009 May;53 Suppl 1:S44-53. doi: 10.1002/mnfr.200800169. [PubMed:18979506 ]
3. Ottaviani JI, Borges G, Momma TY, Spencer JP, Keen CL, Crozier A, Schroeter H: The metabolome of [2-(14)C](-)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives. Sci Rep. 2016 Jul 1;6:29034. doi: 10.1038/srep29034. [PubMed:27363516 ]
4. Borges G, Ottaviani JI, van der Hooft JJJ, Schroeter H, Crozier A: Absorption, metabolism, distribution and excretion of (-)-epicatechin: A review of recent findings. Mol Aspects Med. 2018 Jun;61:18-30. doi: 10.1016/j.mam.2017.11.002. Epub 2017 Nov 9. [PubMed:29126853 ]
5. Gomez-Juaristi M, Sarria B, Martinez-Lopez S, Bravo Clemente L, Mateos R: Flavanol Bioavailability in Two Cocoa Products with Different Phenolic Content. A Comparative Study in Humans. Nutrients. 2019 Jun 26;11(7):1441. doi: 10.3390/nu11071441. [PubMed:31247980 ]
6. Ottaviani JI, Momma TY, Kuhnle GK, Keen CL, Schroeter H: Structurally related (-)-epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards. Free Radic Biol Med. 2012 Apr 15;52(8):1403-12. doi: 10.1016/j.freeradbiomed.2011.12.010. Epub 2011 Dec 23. [PubMed:22240152 ]
7. Ottaviani JI, Momma TY, Heiss C, Kwik-Uribe C, Schroeter H, Keen CL: The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo. Free Radic Biol Med. 2011 Jan 15;50(2):237-44. doi: 10.1016/j.freeradbiomed.2010.11.005. Epub 2010 Nov 11. [PubMed:21074608 ]
8. Mullen W, Borges G, Donovan JL, Edwards CA, Serafini M, Lean ME, Crozier A: Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. Am J Clin Nutr. 2009 Jun;89(6):1784-91. doi: 10.3945/ajcn.2008.27339. Epub 2009 Apr 29. [PubMed:19403635 ]
9. Barnett CF, Moreno-Ulloa A, Shiva S, Ramirez-Sanchez I, Taub PR, Su Y, Ceballos G, Dugar S, Schreiner G, Villarreal F: Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers. Food Funct. 2015 Mar;6(3):824-33. doi: 10.1039/c4fo00596a. [PubMed:25598082 ]