Identification

PhytoHub ID
PHUB000265
Name
(-)-Epigallocatechin 3-O-gallate
Systematic Name
(−)-Epigallocatechin-3-O-gallate
Synonyms
  • EGCG
CAS Number
Not Available
Average Mass
458.375
Monoisotopic Mass
458.0849114
Chemical Formula
C22H18O11
IUPAC Name
(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
InChI Key
WMBWREPUVVBILR-WIYYLYMNSA-N
InChI Identifier
InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1
SMILES
OC1=CC(O)=C2C[C@@H](OC(=O)C3=CC(O)=C(O)C(O)=C3)[C@H](OC2=C1)C1=CC(O)=C(O)C(O)=C1
Structure

Calculated Properties

Solubility (ALOGPS)
7.28e-02 g/l
LogS (ALOGPS)
-3.80
LogP (ALOGPS)
2.38
Hydrogen Acceptors
10
Hydrogen Donors
8
Rotatable Bond Count
4
Polar Surface Area
197.36999999999998
Refractivity
111.74529999999999
Polarizability
42.62355309481916
Formal Charge
0
Physiological Charge
0
pKa (strongest basic)
-5.423934990004845
pKa (strongest acidic)
7.992993558286566
Number of Rings
4
Rule of Five
No
Bioavailability
Yes
Ghose Filter
Yes
Veber's Rule
No
MDDR-like Rule
No

Taxonomy as Food Phytochemical

Family
Polyphenols
Class
Flavonoids
Sub-class
Flavan-3-ols

Spectra from Online Resources

Record IDSourceDescriptionView
TY000083MassBankLC-ESI-ITTOF Spectrum - -, [M+H]+View Spectra

Food Sources

NameGroup
Black teaTeas and herbal teas PublicationsShow
Green teaTeas and herbal teas PublicationsShow

Role as Biomarker of intake

No roles as Biomarker of intake found

Metabolism

Food PhytochemicalMetaboliteSpeciesBiofluidsOriginTMaxCMaxUrinary ExcretionFormulaMonoisotopic mass
(-)-Epigallocatechin 3-O-gallate (-)-Epigallocatechin 3-O-gallatehumanplasmaunchanged1h-3h0.5-2µmol/LNot AvailableC22H18O11458.0849114 Detailed Intervention Studies Publications
(-)-Epigallocatechin 3-O-gallate (Epi)gallocatechin-3-O-gallate O-sulfatehumanileal fluid, plasmaNot AvailableNot AvailableNot AvailableNot AvailableC22H18O14S538.4410395 Publications
(-)-Epigallocatechin 3-O-gallate O-Methyl(epi)gallocatechin-3-O-gallate O-sulfatehumanileal fluidNot AvailableNot AvailableNot AvailableNot AvailableC23H20O14S552.4680283 Publications
(-)-Epigallocatechin 3-O-gallate 5-(3’,4’,5’-trihydroxyphenyl)-gamma-valerolactonehumanNot Availablegut microbiota metaboliteNot AvailableNot AvailableNot AvailableC11H12O5224.068473486 Publications

Inter-Individual Variations in Metabolism

Food PhytochemicalMetaboliteEffectValue
(-)-Epigallocatechin 3-O-gallate (-)-Epigallocatechin 3-O-gallateGenotypeNo effect Publications
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