PhytoHub is the first online database to inventory all phytochemicals present in foods commonly ingested with human diets. It will compile data scattered in more than 20 databases as well as data manually extracted by experts from the literature, or experimentally obtained in collaborative platforms. Sources

It has been designed for use in nutritional metabolomics and in the field of the health effects of plant foods and their phytochemicals. Users will be able to browse PhytoHub or make simple queries by food source, phytochemical name, molecular formula, monoisotopic mass, or MS/MS fragments, as well as more advanced queries. PhytoHub can for example list all the phytochemical precursors & metabolites matching with a monoisotopic mass found in a metabolomic profile, or list all the phytochemical metabolites expected in biological fluids after consumption of a given food.


Version 1.0

The PhytoHub database version 1.0 was developed at INRA, UMR1019 Human Nutrition Unit (Clermont-Ferrand, France), in collaboration with In Siliflo, Inc. (now OMx, Inc.) (Edmonton, Canada).

Initial Contributors

New Contributors

A major strength of PhytoHub is its curation by experts of the different families of phytochemicals:

Compound familyExpertsAffiliation
AlkylresorcinolsRikard LandbergSwedish University of Agricultural Sciences, Uppsala, Sweden
AnthocyaninsWieslaw WiczkowskiInstitute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland
BetalainesWieslaw WiczkowskiInstitute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland
CarotenoidsCatherine Caris-Veyrat, Rachel KopecINRA Avignon, UMR408, France
EllagitanninsPaco Tomas-Barberan, Rocio Garcia-VillalbaCEBAS-CSIC, Murcia, Spain
Flavanol metabolitesPeter HollmanRIKILT Wageningen University, The Netherlands
Flavonol metabolitesClaudia Nunes dos SantosiBET, Oeiras, Portugal
Hydroxycinnamic acidsAndreia Bento da Silva, Maria Rosario BronzeInstitute of Chemical and Biological Technology (ITQB), Oeiras, Lisbon, Portugal
Miscellaneous phenolic acidsAndreia Bento da Silva, Maria Rosario BronzeInstitute of Chemical and Biological Technology (ITQB), Oeiras, Lisbon, Portugal
PhytoprostanesCécile GladineINRA Clermont-Ferrand, UMR1019, France
PhytosterolsLaura NyströmInstitute of Food, Nutrition and Health, ETH Zurich, Switzerland
Procyanidin metabolitesBegoña Bartolomé SualdeaInstituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, Madrid, Spain
StilbenesMireia Urpi-SardaUniversity of Barcelona, Spain
TerpenoidsYoann FillâtreEuropean Research Institute on Natural Ingredients, Grasse, France

Andreia Bento da Silva (PhD student at Institute of Chemical and Biological Technology, Lisboa, Portugal) coordinated the collection of more than 385 compounds, mainly polyphenol metabolites, with their chemical structures, and more than 420 relations between precursors and metabolites with associated references, in the framework of a Short Term Scientific Mission at INRA funded by the COST Action POSITIVe FA 1403 in 2016.

Balthazar Pavot (Biological computing engineer at the INRA Exploration Metabolism PlatForm, Clermont-Ferrand, France) designed and implemented the web portal for PhytoHUB contributors. He was in charge of producing and managing the data aggregating pipeline and the PhytoHUB online updates. His contract at INRA was funded by the JPI Healthy Diet for Healthy Life through the FOODBALL project.

New contributors with expertise on food phytochemicals are welcome. Please contact us if you are interested to join the project.

Any feedback on PhytoHub data is useful !

Funding

The development of PhytoHub 1.0 was supported by INRA and by the French National Agency of Research (ANR) (Project ALIA2010-007- PhenoMeNEP “Phenotyping using Metabolomics for Nutritional Epidemiology”).

It is further developed in the framework of the FoodBAll project funded by the JPI Healthy Diet for Healthy Life. The COST Action POSITIVe is also supporting PhytoHub through generating or compiling knowledge on plant food bioactives.

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