Publications for the metabolite Genistein with food phytochemical Genistein

1. Manach C, Williamson G, Morand C, Scalbert A, Remesy C: Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 2005 Jan;81(1 Suppl):230S-242S. doi: 10.1093/ajcn/81.1.230S. [PubMed:15640486 ]
2. Rowland I, Faughnan M, Hoey L, Wahala K, Williamson G, Cassidy A: Bioavailability of phyto-oestrogens. Br J Nutr. 2003 Jun;89 Suppl 1:S45-58. doi: 10.1079/BJN2002796. [PubMed:12725656 ]
3. Ahn-Jarvis JH, Clinton SK, Grainger EM, Riedl KM, Schwartz SJ, Lee ML, Cruz-Cano R, Young GS, Lesinski GB, Vodovotz Y: Isoflavone pharmacokinetics and metabolism after consumption of a standardized soy and soy-almond bread in men with asymptomatic prostate cancer. Cancer Prev Res (Phila). 2015 Nov;8(11):1045-54. doi: 10.1158/1940-6207.CAPR-14-0465. Epub 2015 Aug 14. [PubMed:26276749 ]
4. Anupongsanugool E, Teekachunhatean S, Rojanasthien N, Pongsatha S, Sangdee C: Pharmacokinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women. BMC Clin Pharmacol. 2005 Mar 3;5:2. doi: 10.1186/1472-6904-5-2. [PubMed:15743537 ]
5. Benvenuti C, Setnikar I: Effect of Lactobacillus sporogenes on oral isoflavones bioavailability: single dose pharmacokinetic study in menopausal women. Arzneimittelforschung. 2011;61(11):605-9. doi: 10.1055/s-0031-1300562. [PubMed:22232848 ]
6. Bitto A, Burnett BP, Polito F, Russo S, D'Anna R, Pillai L, Squadrito F, Altavilla D, Levy RM: The steady-state serum concentration of genistein aglycone is affected by formulation: a bioequivalence study of bone products. Biomed Res Int. 2013;2013:273498. doi: 10.1155/2013/273498. Epub 2012 Dec 31. [PubMed:23484100 ]
7. Burnett BP, Pillai L, Bitto A, Squadrito F, Levy RM: Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women. Int J Womens Health. 2011;3:139-50. doi: 10.2147/IJWH.S19309. Epub 2011 May 9. [PubMed:21792336 ]
8. Yang Z, Kulkarni K, Zhu W, Hu M: Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer Agents Med Chem. 2012 Dec;12(10):1264-80. doi: 10.2174/187152012803833107. [PubMed:22583407 ]
9. Cassidy A, Brown JE, Hawdon A, Faughnan MS, King LJ, Millward J, Zimmer-Nechemias L, Wolfe B, Setchell KD: Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr. 2006 Jan;136(1):45-51. doi: 10.1093/jn/136.1.45. [PubMed:16365057 ]
10. Hernandez G, Zhao L, Franke AA, Chen YL, Mack WJ, Brinton RD, Schneider LS: Pharmacokinetics and safety profile of single-dose administration of an estrogen receptor beta-selective phytoestrogenic (phytoSERM) formulation in perimenopausal and postmenopausal women. Menopause. 2018 Feb;25(2):191-196. doi: 10.1097/GME.0000000000000984. [PubMed:28926513 ]
11. Howes J, Waring M, Huang L, Howes LG: Long-term pharmacokinetics of an extract of isoflavones from red clover (Trifolium pratense). J Altern Complement Med. 2002 Apr;8(2):135-42. doi: 10.1089/107555302317371424. [PubMed:12006121 ]
12. Limopasmanee W, Chansakaow S, Rojanasthien N, Manorot M, Sangdee C, Teekachunhatean S: Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women. Biomed Res Int. 2015;2015:902702. doi: 10.1155/2015/902702. Epub 2015 Jun 4. [PubMed:26146635 ]
13. Metzner JE, Frank T, Kunz I, Burger D, Riegger C: Study on the pharmacokinetics of synthetic genistein after multiple oral intake in post-menopausal women. Arzneimittelforschung. 2009;59(10):513-20. doi: 10.1055/s-0031-1296435. [PubMed:19998579 ]
14. Nagino T, Kano M, Masuoka N, Kaga C, Anbe M, Miyazaki K, Kamachi K, Isozaki M, Suzuki C, Kasuga C, Tanaka A: Intake of a fermented soymilk beverage containing moderate levels of isoflavone aglycones enhances bioavailability of isoflavones in healthy premenopausal Japanese women: a double-blind, placebo-controlled, single-dose, crossover trial. Biosci Microbiota Food Health. 2016;35(1):9-17. doi: 10.12938/bmfh.2015-011. Epub 2015 Sep 26. [PubMed:26858926 ]
15. Rodriguez-Morato J, Farre M, Perez-Mana C, Papaseit E, Martinez-Riera R, de la Torre R, Pizarro N: Pharmacokinetic Comparison of Soy Isoflavone Extracts in Human Plasma. J Agric Food Chem. 2015 Aug 12;63(31):6946-53. doi: 10.1021/acs.jafc.5b02891. Epub 2015 Aug 3. [PubMed:26186408 ]
16. Setchell KD, Brzezinski A, Brown NM, Desai PB, Melhem M, Meredith T, Zimmer-Nechimias L, Wolfe B, Cohen Y, Blatt Y: Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women. J Agric Food Chem. 2005 Mar 23;53(6):1938-44. doi: 10.1021/jf0488099. [PubMed:15769117 ]
17. Teekachunhatean S, Pongnad P, Rojanasthein N, Manorot M, Sangdee C: Effects of vitamin d plus calcium supplements on pharmacokinetics of isoflavones in thai postmenopausal women. Evid Based Complement Alternat Med. 2011;2011:895471. doi: 10.1155/2011/895471. Epub 2011 May 3. [PubMed:21687791 ]
18. Ullmann U, Metzner J, Frank T, Cohn W, Riegger C: Safety, tolerability, and pharmacokinetics of single ascending doses of synthetic genistein (Bonistein) in healthy volunteers. Adv Ther. 2005 Jan-Feb;22(1):65-78. doi: 10.1007/BF02850186. [PubMed:15943224 ]
19. Ullmann U, Oberwittle H, Grossmann M, Riegger C: Repeated oral once daily intake of increasing doses of the novel synthetic genistein product Bonistein in healthy volunteers. Planta Med. 2005 Oct;71(10):891-6. doi: 10.1055/s-2005-864186. [PubMed:16254818 ]
20. Vergne S, Bennetau-Pelissero C, Lamothe V, Chantre P, Potier M, Asselineau J, Perez P, Durand M, Moore N, Sauvant P: Higher bioavailability of isoflavones after a single ingestion of a soya-based supplement than a soya-based food in young healthy males. Br J Nutr. 2008 Feb;99(2):333-44. doi: 10.1017/S0007114507803953. Epub 2007 Aug 3. [PubMed:17678570 ]
21. Vergne S, Titier K, Bernard V, Asselineau J, Durand M, Lamothe V, Potier M, Perez P, Demotes-Mainard J, Chantre P, Moore N, Bennetau-Pelissero C, Sauvant P: Bioavailability and urinary excretion of isoflavones in humans: effects of soy-based supplements formulation and equol production. J Pharm Biomed Anal. 2007 Mar 12;43(4):1488-94. doi: 10.1016/j.jpba.2006.10.006. Epub 2006 Nov 15. [PubMed:17110073 ]
22. Yuan B, Zhen H, Jin Y, Xu L, Jiang X, Sun S, Li C, Xu H: Absorption and plasma disposition of genistin differ from those of genistein in healthy women. J Agric Food Chem. 2012 Feb 15;60(6):1428-36. doi: 10.1021/jf204421c. Epub 2012 Feb 3. [PubMed:22256777 ]
23. Zeng X, Feng Y, Yang L, Huang Y, Zhou D, Sun J, Liu Y, Deng Y: Single- and multiple-dose pharmacokinetics of genistein capsules in healthy chinese subjects: A phase I, randomized, open-label study. Curr Ther Res Clin Exp. 2008 Aug;69(4):318-33. doi: 10.1016/j.curtheres.2008.08.006. [PubMed:24692809 ]
24. Nielsen IL, Williamson G: Review of the factors affecting bioavailability of soy isoflavones in humans. Nutr Cancer. 2007;57(1):1-10. doi: 10.1080/01635580701267677. [PubMed:17516857 ]
25. Chang Y, Choue R: Plasma pharmacokinetics and urinary excretion of isoflavones after ingestion of soy products with different aglycone/glucoside ratios in South Korean women. Nutr Res Pract. 2013 Oct;7(5):393-9. doi: 10.4162/nrp.2013.7.5.393. Epub 2013 Oct 1. [PubMed:24133619 ]
26. Shinkaruk S, Durand M, Lamothe V, Carpaye A, Martinet A, Chantre P, Vergne S, Nogues X, Moore N, Bennetau-Pelissero C: Bioavailability of glycitein relatively to other soy isoflavones in healthy young Caucasian men. Food Chem. 2012 Dec 1;135(3):1104-11. doi: 10.1016/j.foodchem.2012.03.135. Epub 2012 May 22. [PubMed:22953831 ]
27. Simons AL, Renouf M, Murphy PA, Hendrich S: Greater apparent absorption of flavonoids is associated with lesser human fecal flavonoid disappearance rates. J Agric Food Chem. 2010 Jan 13;58(1):141-7. doi: 10.1021/jf902284u. [PubMed:19921837 ]
28. Hutchins AM, Slavin JL, Lampe JW: Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. J Am Diet Assoc. 1995 May;95(5):545-51. doi: 10.1016/S0002-8223(95)00149-2. [PubMed:7722188 ]
29. Lu LJ, Grady JJ, Marshall MV, Ramanujam VM, Anderson KE: Altered time course of urinary daidzein and genistein excretion during chronic soya diet in healthy male subjects. Nutr Cancer. 1995;24(3):311-23. doi: 10.1080/01635589509514420. [PubMed:8610050 ]