Intervention Studies for the metabolite (-)-Epicatechin 3'-O-glucuronide with food phytochemical (-)-Epicatechin

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	3	Healthy; Age=33 y; BMI=27.2 kg/m2	50 mg	Single		1±(0.5-2.0) (IR)	71,3±22,3 (SEM)	239,6	(0-6h)	1,90±0,07 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	3	Healthy; Age=33 y; BMI=27.2 kg/m2	100 mg	Single		1±(1.0-2.0) (IR)	355,3±124 (SEM)	959,5	(0-6h)	1,50±0,04 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	3	Healthy; Age=33 y; BMI=27.2 kg/m2	200 mg	Single		1±(0.5-1.0) (IR)	1092±194,1 (SEM)	2972	(0-6h)	1,30±0,04 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	4	Healthy; 4 M; Age=33 y; BMI=27.2±3.7 kg/m2	50 mg	Single		1±1 (IR)	344±48,7 (SEM)	762,3	(0-6h)	1,20±0,1 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	4	Healthy; 4 M; Age=33 y; BMI=27.2±3.7 kg/m2	50 mg	Multiple	5 days (1 dose daily)	1±(0.5-2.0) (IR)	100,2±70,4 (SEM)	261,73	(0-6h)	1,20±0,2 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	4	Healthy; 4 M; Age=25.5 y; BMI=23.2± 1kg/m2	100 mg	Multiple	1 day (2 doses daily)	1±(0.5-1.0) (IR)	85,4±16,3 (SEM)	242,5	(0-6h)	1,70±0,18 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	4	Healthy; 4 M; Age=25.5 y; BMI=23.2± 1kg/m2	100 mg	Multiple	5 days (2 doses daily)	1,5±(0.5-2.0) (IR)	108,2±80,2 (SEM)	299,5	(0-6h)	1,50±0,17 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma; Urine	Host metabolism	15 g of cocoa + 200 mL of milk	Food	13	Healthy; 3 M; 10 F; Age M=26.67±3.21 y; BMI M=22.47±2.97 kg/m2. Age F=32.60±9.85 y. BMI F=23.36±3.73 kg/m2	68.2 µmol	Single		1,5±0,5 (SD)	0,025±0,001 (SD)	0,072	(0-8h)		0,9120234604	0.622±0,13 µmol (SD) ((0-24h))	Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma; Urine	Host metabolism	25 g of flavanol-rich cocoa + 200 mL of milk	Food	13	Healthy; 3 M; 10 F; Age M=26.67±3.21 y; BMI M=22.47±2.97 kg/m2. Age F=32.60±9.85 y. BMI F=23.36±3.73 kg/m2	235.1 µmol	Single		1,4±0,8 (SD)	0,037±0,001 (SD)	0,11	(0-8h)		0,7031050617	1.653±0,462 µmol (SD) ((0-24h))	Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-glucuronide	Human	Plasma	Host metabolism	cocoa dairy-based drink	Food	10	Healthy; Age=32±1 y; BMI=24±2 kg/m2	1100 mg	Single		2	589±85 (SEM)						Publications

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