Intervention Studies for the metabolite (-)-Epicatechin 3'-O-sulfate with food phytochemical (-)-Epicatechin

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	3	Healthy; Age=33 y; BMI=27.2 kg/m2	50 mg	Single		2±(1.0-2.0) (IR)	240±49,5 (SEM)	729,3	(0-6h)	1,39±0,08 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	3	Healthy; Age=33 y; BMI=27.2 kg/m2	100 mg	Single		2±(1.0-2.0) (IR)	586,5±93,9 (SEM)	1604	(0-6h)	1,28±0,02 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	3	Healthy; Age=33 y; BMI=27.2 kg/m2	200 mg	Single		2±(1.0-2.0) (IR)	1258±98,5 (SEM)	4081,1	(0-6h)	1,22±0,07 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	4	Healthy; 4 M; Age=33 y; BMI=27.2±3.7 kg/m2	50 mg	Single		1±(1.0-2.0) (IR)	433,5±351,1 (SEM)	1221	(0-6h)	1,02±0,1 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	4	Healthy; 4 M; Age=33 y; BMI=27.2±3.7 kg/m2	50 mg	Multiple	5 days (1 dose daily)	2±(1.0-2.0) (IR)	645,67±495,8 (SEM)	1311	(0-6h)	1,06±0,2 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	4	Healthy; 4 M; Age=25.5 y; BMI=23.2± 1kg/m2	100 mg	Multiple	1 day (2 doses daily)	1±(0.5-1.0) (IR)	140,4±52 (SEM)	407,8	(0-6h)	1,15±0,16 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma	Host metabolism	(−)-epicatechin powder + 40 mL of water	Pure compound	4	Healthy; 4 M; Age=25.5 y; BMI=23.2± 1kg/m2	100 mg	Multiple	5 days (2 doses daily)	1,5±(0.5-2.0) (IR)	121,5±73,8 (SEM)	363,6	(0-6h)	1,47±0,15 (SEM)			Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma; Urine	Host metabolism	15 g of cocoa + 200 mL of milk	Food	13	Healthy; 3 M; 10 F; Age M=26.67±3.21 y; BMI M=22.47±2.97 kg/m2. Age F=32.60±9.85 y. BMI F=23.36±3.73 kg/m2	68.2 µmol	Single		1±0,1 (SD)	0,026±0,003 (SD)	0,101	(0-8h)		3,54398827	2.417±0,439 µmol (SD) ((0-24h))	Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma; Urine	Host metabolism	25 g of flavanol-rich cocoa + 200 mL of milk	Food	13	Healthy; 3 M; 10 F; Age M=26.67±3.21 y; BMI M=22.47±2.97 kg/m2. Age F=32.60±9.85 y. BMI F=23.36±3.73 kg/m2	235.1 µmol	Single		1,2±0,5 (SD)	0,042±0,004 (SD)	0,109	(0-8h)		3,129306678	7.357±1,523 µmol (SD) ((0-24h))	Publications
	(-)-Epicatechin		(-)-Epicatechin 3'-O-sulfate	Human	Plasma	Host metabolism	cocoa dairy-based drink	Food	10	Healthy; Age=32±1 y; BMI=24±2 kg/m2	1100 mg	Single		2	331±26 (SEM)						Publications

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