Intervention Studies for the metabolite (-)-Epicatechin 5-O-sulfate with food phytochemical (-)-Epicatechin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (-)-Epicatechin | (-)-Epicatechin 5-O-sulfate | Human | Plasma | Host metabolism | cocoa dairy-based drink | Food | 10 | Healthy; Age=32±1 y; BMI=24±2 kg/m2 | 1100 mg | Single | 2 | 37±3 (SEM) | Publications | ||||||||
| (-)-Epicatechin | (-)-Epicatechin 5-O-sulfate | Human | Plasma | Host metabolism | low-flavanol cocoa-based dairy drink containing (-)-epicatechin | Food | 7 | Healthy; Age = 28 ± 3 y; BMI= 24 ± 1 kg/m2 | 157,7 mg | Single | 2 | 50±6 (SEM) | Publications | ||||||||
| (-)-Epicatechin | (-)-Epicatechin 5-O-sulfate | Human | Plasma; Urine | Host metabolism | 50 mL of solution + 60 mg of 14C-Epicatechin | Pure compound | 8 | Healthy; 8 M; Age=31±3; BMI=24.5±3.3 kg/m2 | 207 µmol | Single | 0,8±0,1 (SEM) | 32±4 (SEM) | 92 | (0-24h) | 1,90±0,3 (SEM) | 0,6280193237 | 1.3±0,2 µmol (SEM) ((0-48h)) | Publications | |||
| (-)-Epicatechin | (-)-Epicatechin 5-O-sulfate | Human | Urine | Host metabolism | 100 g of 70 % dark chocolate | Food | 5 | Healthy; Age=23.4±3.3 y; BMI=22±2 kg/m2 | 154 mg | Single | 0,3 | 1.15±0,2 µmol (SEM) ((0-24h)) | Publications |