Intervention Studies for the metabolite (-)-Epicatechin 5-O-sulfate with food phytochemical (-)-Epicatechin

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	(-)-Epicatechin		(-)-Epicatechin 5-O-sulfate	Human	Plasma	Host metabolism	cocoa dairy-based drink	Food	10	Healthy; Age=32±1 y; BMI=24±2 kg/m2	1100 mg	Single		2	37±3 (SEM)						Publications
	(-)-Epicatechin		(-)-Epicatechin 5-O-sulfate	Human	Plasma	Host metabolism	low-flavanol cocoa-based dairy drink containing (-)-epicatechin	Food	7	Healthy; Age = 28 ± 3 y; BMI= 24 ± 1 kg/m2	157,7 mg	Single		2	50±6 (SEM)						Publications
	(-)-Epicatechin		(-)-Epicatechin 5-O-sulfate	Human	Plasma; Urine	Host metabolism	50 mL of solution + 60 mg of 14C-Epicatechin	Pure compound	8	Healthy; 8 M; Age=31±3; BMI=24.5±3.3 kg/m2	207 µmol	Single		0,8±0,1 (SEM)	32±4 (SEM)	92	(0-24h)	1,90±0,3 (SEM)	0,6280193237	1.3±0,2 µmol (SEM) ((0-48h))	Publications
	(-)-Epicatechin		(-)-Epicatechin 5-O-sulfate	Human	Urine	Host metabolism	100 g of 70 % dark chocolate	Food	5	Healthy; Age=23.4±3.3 y; BMI=22±2 kg/m2	154 mg	Single							0,3	1.15±0,2 µmol (SEM) ((0-24h))	Publications

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