Intervention Studies for the metabolite Trigonelline with food phytochemical Trigonelline
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 35mL coffee | food | 10 | Healthy; M | 592.28 µmol | Multiple | 1 month (one morning dose) | 2.9±0.18 (SEM) | 1.9±0.16 (SEM) | 19.75 | 0-24h | 43.69 | 258.76±25.96 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 35mL coffee | food | 11 | Healthy; F | 592.28 µmol | Multiple | 1 month (one morning dose) | 3.09±0.21 (SEM) | 2.72±0.21 (SEM) | 26.97 | 0-24h | 34.49 | 204.29±20.71 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 105 mL coffee | food | 10 | Healthy; M | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 8.4±0.16 (SEM) | 4.87±0.61 (SEM) | 63.56 | 0-24h | 33.34 | 592.35±62.59 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 105 mL coffee | food | 11 | Healthy; F | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 8.55±0.21 (SEM) | 7.27±0.61 (SEM) | 99.59 | 0-24h | 30.36 | 539.46±42.77 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 35 mL coffe + 2 cocoa products | food | 10 | Healthy; M | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 4.1±0.65 (SEM) | 2.27±0.15 (SEM) | 31.72 | 0-24h | 58.06 | 358.42±43.75 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 35 mL coffe + 2 cocoa products | food | 11 | Healthy; F | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 4±0.25 (SEM) | 3.34±0.28 (SEM) | 45.26 | 0-24h | 50.26 | 310.26±33 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 35mL coffee | food | 8 | Healthy; Smokers | 592.28 µmol | Multiple | 1 month (one morning dose) | 2.88±0.13 (SEM) | 2.28±0.23 (SEM) | 25.31 | 0-24h | 38.50 | 228.04±26.76 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 35mL coffee | food | 13 | Healthy; Non-smokers | 592.28 µmol | Multiple | 1 month (one morning dose) | 3.08±0.21 (SEM) | 2.36±0.22 (SEM) | 22.44 | 0-24h | 39.10 | 231.58±23.09 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 105 mL coffee | food | 8 | Healthy; Smokers | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 8.63±0.18 (SEM) | 6.71±0.81 (SEM) | 90.84 | 0-24h | 34.86 | 619.42±60.89 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 105 mL coffee | food | 13 | Healthy; Non-smokers | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 8.38±0.18 (SEM) | 5.77±0.63 (SEM) | 77.26 | 0-24h | 29.88 | 530.94±45.43 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 35 mL coffe + 2 cocoa products | food | 8 | Healthy; Smokers | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 4.43±0.73 (SEM) | 2.86±0.47 (SEM) | 39.36 | 0-24h | 53.04 | 327.42±43.81 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 35 mL coffe + 2 cocoa products | food | 13 | Healthy; Non-smokers | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 3.85±0.34 (SEM) | 2.78±0.18 (SEM) | 38.02 | 0-24h | 54.55 | 336.74±35.47 µmol (SEM) (0-24h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 350 mL coffee | food | 6 | Healthy; F (age 24-28 y) | 1005.96 µmol | Single | 3.17 | 6547±17.3 (SD) | 40430 | 0-8h | 5.50 | 46.20±7.40 (SD) | 373450±16.1 nmol (SD) (0-8h) | Publications | |||
| Trigonelline | Trigonelline | Human | Plasma; Urine | Unchanged | 350 mL coffee | food | 7 | Healthy; M (age 27-30 y) | 1005.96 µmol | Single | 2.29 | 5479±13.6 (SD) | 31716 | 0-8h | 4.65 | 57.40±6.90 (SD) | 464590±20.1 nmol (SD) (0-8h) | Publications |