Intervention Studies for the metabolite N-Methylnicotinamide with food phytochemical Coffee pyrimidines
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 35mL coffee | food | 10 | Healthy; M | 592.28 µmol | Multiple | 1 month (one morning dose) | 1.8±0.57 (SEM) | 0.39±0.03 (SEM) | 2.44 | 0-24h | 24.41 | 144.58±19.75 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 35mL coffee | food | 11 | Healthy; F | 592.28 µmol | Multiple | 1 month (one morning dose) | 1.27±0.26 (SEM) | 0.54±0.07 (SEM) | 2.06 | 0-24h | 24.26 | 143.66±29.04 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 105 mL coffee | food | 10 | Healthy; M | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 3.5±0.73 (SEM) | 0.59±0.06 (SEM) | 6.01 | 0-24h | 7.60 | 134.96±20.33 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 105 mL coffee | food | 11 | Healthy; F | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 3±0.65 (SEM) | 0.61±0.05 (SEM) | 6.18 | 0-24h | 8.49 | 150.85±19.51 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 35 mL coffe + 2 cocoa products | food | 10 | Healthy; M | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 6.3±0.67 (SEM) | 0.87±0.05 (SEM) | 8.77 | 0-24h | 22.19 | 137.00±12.8 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 35 mL coffe + 2 cocoa products | food | 11 | Healthy; F | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 5.7±0.75 (SEM) | 0.82±0.05 (SEM) | 8.9 | 0-24h | 22.19 | 136.98±19.7 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 35mL coffee | food | 8 | Healthy; Smokers | 592.28 µmol | Multiple | 1 month (one morning dose) | 1.13±0.28 (SEM) | 0.5±0.09 (SEM) | 1.71 | 0-24h | 27.36 | 162.03±34.36 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 35mL coffee | food | 13 | Healthy; Non-smokers | 592.28 µmol | Multiple | 1 month (one morning dose) | 1.77±0.45 (SEM) | 0.45±0.04 (SEM) | 2.57 | 0-24h | 22.47 | 133.07±19.22 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 105 mL coffee | food | 8 | Healthy; Smokers | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 3.56±1.04 (SEM) | 0.55±0.06 (SEM) | 5.53 | 0-24h | 10.28 | 182.61±15.94 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 105 mL coffee | food | 13 | Healthy; Non-smokers | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 3.04±0.47 (SEM) | 0.64±0.05 (SEM) | 6.45 | 0-24h | 6.70 | 119.08±17.21 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 35 mL coffe + 2 cocoa products | food | 8 | Healthy; Smokers | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 5.14±1.03 (SEM) | 0.73±0.05 (SEM) | 7.47 | 0-24h | 24.14 | 149.02±22.6 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methylnicotinamide | Human | Plasma; Urine | Host metabolism | 35 mL coffe + 2 cocoa products | food | 13 | Healthy; Non-smokers | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 6.46±0.5 (SEM) | 0.9±0.07 (SEM) | 9.57 | 0-24h | 20.99 | 129.58±13.15 µmol (SEM) (0-24h) | Publications |