Intervention Studies for the metabolite Nicotinamide with food phytochemical Nicotinamide
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nicotinamide | Nicotinamide | Human | Urine | Unchanged | 350 mL coffee | food | 6 | Healthy; F (age 24-28 y) | 1005.96 µmol | Single | 1.04 | 10.5 µmol (0-8h) | Publications | ||||||||
| Nicotinamide | Nicotinamide | Human | Urine | Unchanged | 350 mL coffee | food | 7 | Healthy; M (age 27-30 y) | 1005.96 µmol | Single | 1.19 | 12 µmol (0-8h) | Publications | ||||||||
| Nicotinamide | Nicotinamide | Human | Plasma | Unchanged | 500 mg gelatine capsules +200 mL water | pure compound | 6 | Healthy; M, age 27-45 y | 1 g | Single | 22.8±2.8 (SEM) | 4.18 ± 0.30 (SEM) mg/mL*min (0-inf) | 0-∞ | 2.7±0.5 (SEM) | Publications | ||||||
| Nicotinamide | Nicotinamide | Human | Plasma | Unchanged | 500 mg gelatine capsules +200 mL water | pure compound | 6 | Healthy; M, age 27-45 y | 3 g | Single | 70.3±7.5 (SEM) | 29.28 ± 3.09 (SEM) mg/mL*min (0-inf) | 0-∞ | 5.9±0.6 (SEM) | Publications | ||||||
| Nicotinamide | Nicotinamide | Human | Plasma | Unchanged | 500 mg gelatine capsules +200 mL water | pure compound | 6 | Healthy; M, age 27-45 y | 6 g | Single | 159.5±15 (SEM) | 99.35 ± 11.46 (SEM) mg/mL*min (0-inf) | 0-∞ | 8.1±1.2 (SEM) | Publications | ||||||
| Nicotinamide | Nicotinamide | Human | Plasma | Unchanged | low dose Nicotinamide + 30 mL water | pure compound | 8 | Healthy; Age 20 y | 0.0025 g/Kg bw | Single | 0.3±0.1 (SD) | 3.3±2.6 (SD) | 3.0 ± 1.4 (SD) µg/mL*h (0-inf) | 0-∞ | 0.6±0.2 (SD) | Publications | |||||
| Nicotinamide | Nicotinamide | Human | Plasma | Unchanged | high dose Nicotinamide + 30 mL water | pure compound | 8 | Healthy; Age 20 y | 0.025 g/Kg bw | Single | 0.5±0.3 (SD) | 42.1±15.2 (SD) | 187.1 ± 51.8 (SD) µg/mL*h (0-inf) | 0-∞ | 3.5±1 (SD) | Publications | |||||
| Nicotinamide | Nicotinamide | Human | Plasma | Unchanged | low-dose Enduramide (sustained release NAM) | pure compound | 8 | Healthy; Age 20 y | 500 mg | Single | 1±0.8 (SD) | 2.1±0.7 (SD) | 4.5 ± 2.2 (SD) µg/mL*h (0-inf) | 0-∞ | 1±0.5 (SD) | Publications | |||||
| Nicotinamide | Nicotinamide | Human | Plasma | Unchanged | high-dose Enduramide (sustained release NAM) | pure compound | 8 | Healthy; Age 20 y | 2 g | Single | 1.9±1.2 (SD) | 16.2±3.5 (SD) | 107.0 ± 41.1 (SD) µg/mL*h (0-inf) | 0-∞ | 2.7±1.6 (SD) | Publications | |||||
| Nicotinamide | Nicotinamide | Human | Urine | Unchanged | tablets + 300-500 mL water | pure compound | 4 | Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y | 1 g | Single | 2.40 | Publications | |||||||||
| Nicotinamide | Nicotinamide | Human | Urine | Unchanged | tablets + 300-500 mL water | pure compound | 4 | Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y | 2 g | Single | 3.90 | Publications | |||||||||
| Nicotinamide | Nicotinamide | Human | Urine | Unchanged | tablets + 300-500 mL water | pure compound | 4 | Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y | 4 g | Single | 8.20 | Publications | |||||||||
| Nicotinamide | Nicotinamide | Human | Urine | Unchanged | tablets + 300-500 mL water | pure compound | 4 | Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y | 6 g | Single | 8.00 | Publications | |||||||||
| Nicotinamide | Nicotinamide | Human | Urine | Unchanged | 500 mL coffee | food | 10 | Healthy; 6 F, 4 M; age 22–27 y, BMI 22.6 ± 2.6 kg/m2 | 35.38 µmol | Single | 7.91 | 2.8 µmol (0-36h) | Publications |