Intervention Studies for the metabolite N-Methyl-4-pyridone-5-carboxamide with food phytochemical Coffee pyrimidines
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 35mL coffee | food | 10 | Healthy; M | 592.28 µmol | Multiple | 1 month (one morning dose) | 3.5±0.93 (SEM) | 2±0.36 (SEM) | 35.17 | 0-24h | 7.53 | 44.58±6.51 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 35mL coffee | food | 11 | Healthy; F | 592.28 µmol | Multiple | 1 month (one morning dose) | 7.68±2.48 (SEM) | 2.18±0.33 (SEM) | 38.26 | 0-24h | 6.24 | 36.95±5.77 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 105 mL coffee | food | 10 | Healthy; M | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 6.3±2.12 (SEM) | 1.96±0.3 (SEM) | 34.15 | 0-24h | 2.65 | 47.07±8.79 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 105 mL coffee | food | 11 | Healthy; F | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 9.73±2.81 (SEM) | 1.84±0.13 (SEM) | 33.25 | 0-24h | 2.05 | 36.37±4.44 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 35 mL coffe + 2 cocoa products | food | 10 | Healthy; M | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 5.45±2.15 (SEM) | 2.08±0.26 (SEM) | 34.85 | 0-24h | 7.04 | 43.44±4.71 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 35 mL coffe + 2 cocoa products | food | 11 | Healthy; F | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 6.6±1.88 (SEM) | 1.83±0.19 (SEM) | 30.76 | 0-24h | 4.67 | 28.84±2.73 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 35mL coffee | food | 8 | Healthy; Smokers | 592.28 µmol | Multiple | 1 month (one morning dose) | 8.56±3.51 (SEM) | 2.21±0.47 (SEM) | 39.47 | 0-24h | 6.95 | 41.18±7.22 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 35mL coffee | food | 13 | Healthy; Non-smokers | 592.28 µmol | Multiple | 1 month (one morning dose) | 3.92±0.57 (SEM) | 2.03±0.27 (SEM) | 35.14 | 0-24h | 6.79 | 40.22±5.58 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 105 mL coffee | food | 8 | Healthy; Smokers | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 11.75±3.67 (SEM) | 2.05±0.27 (SEM) | 34.81 | 0-24h | 2.62 | 46.51±6.04 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 105 mL coffee | food | 13 | Healthy; Non-smokers | 1776.83 µmol | Multiple | 1 month (1 morning dose, 1 dose at 12 am, 1 dose at 3 pm) | 5.85±1.62 (SEM) | 1.8±0.21 (SEM) | 32.99 | 0-24h | 2.16 | 38.37±6.87 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 35 mL coffe + 2 cocoa products | food | 8 | Healthy; Smokers | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 7±2.72 (SEM) | 1.6±0.21 (SEM) | 28.1 | 0-24h | 4.78 | 29.51±3.02 µmol (SEM) (0-24h) | Publications | |||
| Coffee pyrimidines | N-Methyl-4-pyridone-5-carboxamide | Human | Plasma; Urine | Host metabolism | 35 mL coffe + 2 cocoa products | food | 13 | Healthy; Non-smokers | 617.3 µmol | Multiple | 1 month (1 coffe at 9 am, 1 cocoa product at 12 am, 1 cocoa product at 3 pm) | 5.5±1.61 (SEM) | 2.15±0.2 (SEM) | 35.33 | 0-24h | 6.43 | 39.66±4.32 µmol (SEM) (0-24h) | Publications |