Intervention Studies for the metabolite Phylloquinone with food phytochemical Phylloquinone
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 102.4 g of microwaved broccoli | food | 18 | Healthy; 9M (Age=31.2± 1.9, BMI= 26.0± 0.8 kg/m²) ,9F (Age= 30.7 ± 2.1 ; BMI= 23.5± 1.1kg/m²) | 377±46 µg/day | Single | 24h | 16h | 3.5 | 66.8 | 0-24h | 9 | Publications | ||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 102.4 g of microwaved broccoli | food | 18 | Healthy; 9M( Age= 70.0± 1.8 ; BMI=26.0± 1.4 kg/m²); 9F (Age= 0.9 ± 1.6 ; BMI= 26.8± 1.5 kg/m²) | 377±46 µg/day | Single | 24h | 15h | 3.5 | 94.2 | 0-24h | 9 | Publications | ||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | Phylloquinone and Menaquinone-7 | pure compound | 15 | Healthy; Age= 25 - 35 | 1 mg | Single | 96 h | 4 | 13.22 | 1-2 | Publications | ||||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 115g deuterium-labeled broccoli | food | 1 | Healthy; 1M; Age= 23 | 0.168 mg | Single | 24 | 3 | 2.12 | Publications | |||||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | <10µg of phylloquinone + 120 g serving of collard greens | food | 9 | Healthy; 9M; Age=30.4±3.1 | 0.157 mg | Single | 6.11±0.43 (SEM) | 15.1±2.84 (SEM) | 87.1 | 0-72h | 3.08±0.56 (SEM) | Publications | |||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | <10µg of phylloquinone + 120 g serving of collard greens | food | 12 | Healthy; 12F; Age=32.9±3.0 | 0.157 mg | Single | 6.07±0.54 (SEM) | 10.6±2.37 (SEM) | 58.1 | 0-72h | 4.16±0.52 (SEM) | Publications | |||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | <10µg of phylloquinone + 120 g serving of collard greens | food | 12 | Healthy; 12 M; Age=66.3±2.9 | 0.157 mg | Single | 6.43±0.29 (SEM) | 14.1±2.96 (SEM) | 101 | 0-72h | 3.93±0.4 (SEM) | Publications | |||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | <10µg of phylloquinone + 120 g serving of collard greens | food | 9 | Healthy; 9F; Age=68.6 ± 3.6 | 0.157 mg | Single | 6.21±0.15 (SEM) | 16±3.02 (SEM) | 99.8 | 0-72h | 3.64±0.49 (SEM) | Publications | |||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 500µg of phylloquinone +120 g serving of collard greens | food | 9 | Healthy; 9M; Age=30.4±3.1 | 0.157 mg | Single | 5.94±0.29 (SEM) | 12.7±1.97 (SEM) | 69.1 | 0-72h | 2.59±0.63 (SEM) | Publications | |||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 500µg of phylloquinone +120 g serving of collard greens | food | 12 | Healthy; 12F; Age=32.9±3.0 | 0.157 mg | Single | 5.97±0.17 (SEM) | 9.88±1.59 (SEM) | 59.9 | 0-72h | 4.14±0.54 (SEM) | Publications | |||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 500µg of phylloquinone +120 g serving of collard greens | food | 12 | Healthy; 12 M; Age=66.3±2.9 | 0.157 mg | Single | 6.23±0.13 (SEM) | 16.5±2.05 (SEM) | 99.8 | 0-72h | 3.85±0.55 (SEM) | Publications | |||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 500µg of phylloquinone +120 g serving of collard greens | food | 9 | Healthy; 9F; Age=68.6 ± 3.6 | 0.157 mg | Single | 6.36±0.38 (SEM) | 15.6±2.49 (SEM) | 102 | 0-72h | 3.89±0.52 (SEM) | Publications | |||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 100 g of Deuterated Collard Greens | food | 3 | Healthy; M; Age=37±15.56Y;BMI= 25.93±3.16 kg/m² | 0.396±0.028 mg | Single | 6 | 10.51±4.38 (SD) | 22.8 | Publications | |||||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 227 g Boiled Spinach | food | 5 | Healthy; 3M,2F; Age= 25-45 | 2.2 µmol | Single | 8 | 0-10h | Publications | ||||||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | Synthesized phytomenadione | pure compound | 30 | Healthy; 15 M;15F; Age= 22-46 | 2 mg | single | 3.37±1.16 (SD) | 28.66±11 (SD) | 161 | 0-∞ | 6.1±1.35 (SD) | Publications | |||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 400g of 13CLabeled microwaved Kale | food | 7 | Healthy; 4M;3F; Age=46±14, BMI=25±3Kg/m² | 0.156 µmol | Single | 8.8±3.8 (SD) | Publications | |||||||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 102.4 g of microwaved broccoli | food | 18 | Healthy; 9M (Age=31.2± 1.9, BMI= 26.0± 0.8 kg/m²) ,9F (Age= 30.7 ± 2.1 ; BMI= 23.5± 1.1kg/m²) | 377±46 µg/day | Multiple | 17 days | Publications | |||||||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 102.4 g of microwaved broccoli | food | 18 | Healthy; 9M( Age= 70.0± 1.8 ; BMI=26.0± 1.4 kg/m²); 9F (Age= 0.9 ± 1.6 ; BMI= 26.8± 1.5 kg/m²) | 377±46 µg/day | Multiple | 17 days | Publications | |||||||||
| Phylloquinone | Phylloquinone | Human | Plasma | Unchanged | 1 single serving 13CLabeled microwaved Kale | food | 1 | Healthy;1Men; BW=84 Kg | 0.156 µmol | Multiple | 6 weeks | 7 | 3 | Publications |