Intervention Studies for the metabolite N-Methylnicotinamide with food phytochemical Nicotinamide

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Nicotinamide		N-Methylnicotinamide	Human	Serum; Urine	Host metabolism		pure compound	10	Healthy; 6 M and 4 F, age 28-60 y	0.0015 g/Kg bw	Single		1	1.5					230 µmol (0-24h)	Publications
	Nicotinamide		N-Methylnicotinamide	Human	Urine	Host metabolism	tablets + 300-500 mL water	pure compound	4	Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y	1 g	Single							20.20		Publications
	Nicotinamide		N-Methylnicotinamide	Human	Urine	Host metabolism	tablets + 300-500 mL water	pure compound	4	Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y	2 g	Single							25.10		Publications
	Nicotinamide		N-Methylnicotinamide	Human	Urine	Host metabolism	tablets + 300-500 mL water	pure compound	4	Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y	4 g	Single							26.70		Publications
	Nicotinamide		N-Methylnicotinamide	Human	Urine	Host metabolism	tablets + 300-500 mL water	pure compound	4	Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y	6 g	Single							16.80		Publications

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