Intervention Studies for the metabolite N-Methylnicotinamide with food phytochemical Nicotinamide
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nicotinamide | N-Methylnicotinamide | Human | Serum; Urine | Host metabolism | pure compound | 10 | Healthy; 6 M and 4 F, age 28-60 y | 0.0015 g/Kg bw | Single | 1 | 1.5 | 230 µmol (0-24h) | Publications | ||||||||
| Nicotinamide | N-Methylnicotinamide | Human | Urine | Host metabolism | tablets + 300-500 mL water | pure compound | 4 | Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y | 1 g | Single | 20.20 | Publications | |||||||||
| Nicotinamide | N-Methylnicotinamide | Human | Urine | Host metabolism | tablets + 300-500 mL water | pure compound | 4 | Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y | 2 g | Single | 25.10 | Publications | |||||||||
| Nicotinamide | N-Methylnicotinamide | Human | Urine | Host metabolism | tablets + 300-500 mL water | pure compound | 4 | Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y | 4 g | Single | 26.70 | Publications | |||||||||
| Nicotinamide | N-Methylnicotinamide | Human | Urine | Host metabolism | tablets + 300-500 mL water | pure compound | 4 | Healthy; 3 M, 1 F. Age 38.75 ± 1.44 y | 6 g | Single | 16.80 | Publications |