Intervention Studies for the metabolite Sulforaphane with food phytochemical Glucoraphanin

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Glucoraphanin		Sulforaphane	Human	Urine	Host metabolism	Broccoli sprouts with active myrosinase containing 5.18 ± 0,66 µmol/0.64 g DW for sulforaphane and 0.56 ± 0.1 µmol/0.64 g DW for iberin	Food	5	2M; 3F; Age= 22–52Y, Caucasian	0.64 g	Single	24 h						39,7±7 (SD)	2.06 μmol (0-24h)	Publications
	Glucoraphanin		Sulforaphane	Human	Urine	Host metabolism	Broccoli sprouts with inactive myrosinase (C-) containing 10,39 ± 1,48 µmol/0.64 g DW for glucoraphain and 1,3 ± 0.21 µmol/0.64 g DW for glucoiberin	Food	5	2M; 3F; Age= 22–52Y, Caucasian	0.64 g	Single	24 h						6,3±2 (SD)	0.66 μmol (0-24h)	Publications
	Glucoraphanin		Sulforaphane	Human	Urine	Host metabolism	Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin	Food	14	Healthy women; age= 27-36 Y	Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin	Multiple	7 days								Publications
	Glucoraphanin		Sulforaphane	Human	Plasma; Urine	Host metabolism	Broccoli (200g) with 20 g of raw daikon radish	Food	18	Healthy; 8M; 10W; Age=37–65 years; BMI = 19-37 kg/m²	200 g	Multiple	17 days once a day	1-3							Publications
	Glucoraphanin		Sulforaphane	Human	Urine	Host metabolism	Broccoli seed and sprout extract suplement Avmacol® with active myrosinase were taken with and without coat and with and without omeprazole treatment (proton pump inhibitor)	Extract	16	Healthy; Age=24-69 Y; BMI= 18.1-37.4Y	369 μmol of glucoraphanin/day µmol	Single							25.67% (uncoated and no omeprazole); 35.48% (coated and no omeprazole); 33.59% (uncoated and omeprazole); 36.41% (coated and omeprazole)		Publications
	Glucoraphanin		Sulforaphane	Human	Plasma; Urine	Host metabolism	200 g of uncooked broccoli florets	Food	6	Healthy; Age=28-67 Y; BMI= 25.3-28.1Kg/m²	200 g uncooked broccoli florets	Single									Publications
	Glucoraphanin		Sulforaphane	Human	Plasma	Host metabolism	Myrosinase-activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours.	Extract	6	Healthy; F; Age= 18-35Y	32 mg sulforaphane	Single		2 (SEM)	150	485,8	0-8h				Publications
	Glucoraphanin		Sulforaphane	Human	Plasma	Host metabolism	Myrosinase-non activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours.	Extract	6	Healthy; F; Age= 18-35Y	32 mg sulforaphane	Single		0.5 (SEM)	125	317	0-8h				Publications
	Glucoraphanin		Sulforaphane	Human	Plasma; Urine	Host metabolism	Prostaphane ® (2 tablets containing 100 µmol of SFN each)	Extract	10	Healthy;2M;8F; Age= 51.9 Y	Prostaphane ® (2 tablets containing 100 µmol of SFN each)	Single	24 h						71,4		Publications
	Glucoraphanin		Sulforaphane	Human	Plasma	Host metabolism	SFN - αCD (Purified sulforaphane-rich broccoli sprout extract in α-cyclodextrin).	Extract	10	Healthy;3M;7F,Age= 46.5 Y	200 µmol of SFN in 350 mg of SFN - αCD (dosage of the study)	Single	24 h	2,07±0,26	1,33±0,5 (SD)				62,3±20 (SD)		Publications

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