Intervention Studies for the metabolite Sulforaphane with food phytochemical Glucoraphanin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glucoraphanin | Sulforaphane | Human | Urine | Host metabolism | Broccoli sprouts with active myrosinase containing 5.18 ± 0,66 µmol/0.64 g DW for sulforaphane and 0.56 ± 0.1 µmol/0.64 g DW for iberin | Food | 5 | 2M; 3F; Age= 22–52Y, Caucasian | 0.64 g | Single | 24 h | 39,7±7 (SD) | 2.06 μmol (0-24h) | Publications | |||||||
| Glucoraphanin | Sulforaphane | Human | Urine | Host metabolism | Broccoli sprouts with inactive myrosinase (C-) containing 10,39 ± 1,48 µmol/0.64 g DW for glucoraphain and 1,3 ± 0.21 µmol/0.64 g DW for glucoiberin | Food | 5 | 2M; 3F; Age= 22–52Y, Caucasian | 0.64 g | Single | 24 h | 6,3±2 (SD) | 0.66 μmol (0-24h) | Publications | |||||||
| Glucoraphanin | Sulforaphane | Human | Urine | Host metabolism | Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin | Food | 14 | Healthy women; age= 27-36 Y | Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin | Multiple | 7 days | Publications | |||||||||
| Glucoraphanin | Sulforaphane | Human | Plasma; Urine | Host metabolism | Broccoli (200g) with 20 g of raw daikon radish | Food | 18 | Healthy; 8M; 10W; Age=37–65 years; BMI = 19-37 kg/m² | 200 g | Multiple | 17 days once a day | 1-3 | Publications | ||||||||
| Glucoraphanin | Sulforaphane | Human | Urine | Host metabolism | Broccoli seed and sprout extract suplement Avmacol® with active myrosinase were taken with and without coat and with and without omeprazole treatment (proton pump inhibitor) | Extract | 16 | Healthy; Age=24-69 Y; BMI= 18.1-37.4Y | 369 μmol of glucoraphanin/day µmol | Single | 25.67% (uncoated and no omeprazole); 35.48% (coated and no omeprazole); 33.59% (uncoated and omeprazole); 36.41% (coated and omeprazole) | Publications | |||||||||
| Glucoraphanin | Sulforaphane | Human | Plasma; Urine | Host metabolism | 200 g of uncooked broccoli florets | Food | 6 | Healthy; Age=28-67 Y; BMI= 25.3-28.1Kg/m² | 200 g uncooked broccoli florets | Single | Publications | ||||||||||
| Glucoraphanin | Sulforaphane | Human | Plasma | Host metabolism | Myrosinase-activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours. | Extract | 6 | Healthy; F; Age= 18-35Y | 32 mg sulforaphane | Single | 2 (SEM) | 150 | 485,8 | 0-8h | Publications | ||||||
| Glucoraphanin | Sulforaphane | Human | Plasma | Host metabolism | Myrosinase-non activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours. | Extract | 6 | Healthy; F; Age= 18-35Y | 32 mg sulforaphane | Single | 0.5 (SEM) | 125 | 317 | 0-8h | Publications | ||||||
| Glucoraphanin | Sulforaphane | Human | Plasma; Urine | Host metabolism | Prostaphane ® (2 tablets containing 100 µmol of SFN each) | Extract | 10 | Healthy;2M;8F; Age= 51.9 Y | Prostaphane ® (2 tablets containing 100 µmol of SFN each) | Single | 24 h | 71,4 | Publications | ||||||||
| Glucoraphanin | Sulforaphane | Human | Plasma | Host metabolism | SFN - αCD (Purified sulforaphane-rich broccoli sprout extract in α-cyclodextrin). | Extract | 10 | Healthy;3M;7F,Age= 46.5 Y | 200 µmol of SFN in 350 mg of SFN - αCD (dosage of the study) | Single | 24 h | 2,07±0,26 | 1,33±0,5 (SD) | 62,3±20 (SD) | Publications | ||||||
| Glucoraphanin | Sulforaphane | Human | Plasma; Urine | Host metabolism | 200 g of blanched and frozen broccoli (100g in breakfast and 100g in the dinner) ( 147.6μmol ofglucoraphanin and 3.6μmol of glucoerucin). | Food | 18 | Healthy;9M;8F;Age=40-70Y | 200g (the day before the study treated group eat only 100g and the day of the study all volunteers treated and non-treated eat 200g) | Multiple | 17 days | 13 | 24h | 4 | Publications | ||||||
| Glucoraphanin | Sulforaphane | Human | Urine | Host metabolism | Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85 | Food | 21 | Obese ;21 M; Age=40-60 Y; BMI= 24.9-29.9 kg/m² | 30 g / day | Multiple | 85 days | 0.0042 nmol/mg creatinine (day 0); 04604 nmol/mg creatinine (day 35); 0.0068 nmol/mg creatinine (day 50); 0.00113 nmol/mg creatinine (day 85)±0.101-0.5639 nmol/mg creatinine (day 0); 0.3659-0.9188nmol/mg creatinine (day 35);0.0005-0.0091nmol/mg creatinine (day 50); 0.1827-0.5354 nmol/mg creatinine (day 85) (CI) | Publications | ||||||||
| Glucoraphanin | Sulforaphane | Human | Urine | Host metabolism | The treatment were applied during 10 weeks (70 days) and samples were taken on day 0 and 70 and after the treatment on day 90 and 160) | Food | 40 | Obese; Age= 35-55 Y; BMI= 24.9- 29.9 kg/m² | 30 g per day | Multiple | 70 days | 0.098 µM (day 0); 0.543 µM(day 70); 0.038 µM (day 90); 0.022 µM (day 160)±0-0.23 µM (day 0); 0.4-0.69 µM(day 70); 0.0-0.13 µM (day 90); 0.01-0.03 µM (day 160) (CI) | Publications | ||||||||
| Glucoraphanin | Sulforaphane | Human | Urine | Host metabolism | Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85 | Food | 19 | Obese;19 non-menauposal F; Age=40-60 Y; BMI= 24.9-29.9 kg/m² | 30 g / day | Multiple | 85 days | 0.0663 nmol/mg creatinine (day 0); 0.4989 nmol/mg creatinine (day 35); 0.0027nmol/mg creatinine (day 50); 0.0128 nmol/mg creatinine (day 85)±0.1291-0.801 nmol/mg creatinine (day 0); 0.5029-0.8521 nmol/mg creatinine (day 35); 0.1147-0.4704 nmol/mg creatinine (day 50); 0.1799-1.1452 nmol/mg creatinine (day 85) (CI) | Publications | ||||||||
| Glucoraphanin | Sulforaphane | Human | Urine | Host metabolism | Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85 | Food | 19 | Obese;19 post-menauposal F; Age=40-60 Y; BMI= 24.9-29.9 kg/m² | 30 g / day | Multiple | 85 days | 0.0409 nmol/mg creatinine (day 0); 0.8937 nmol/mg creatinine (day 35); 0.0073 nmol/mg creatinine (day 50); 0.004 nmol/mg creatinine (day 85)±0.2123-1.0058 nmol/mg creatinine (day 0); 0.1771-0.8034 nmol/mg creatinine (day 35); 0.1527-0.5762 nmol/mg creatinine (day 50); 0.0171-1.1182 nmol/mg creatinine (day 85) (CI) | Publications | ||||||||
| Glucoraphanin | Sulforaphane | Human | Plasma | Host metabolism | Gel Capsule: Oral formulation extracted from broccoli sprouts containing 100 µmol SFN | Extract | 17 | Patients with with skin melanoma; 5M; 12F; Age= 22-66 years old | 100 µmol SFN | Multiple | 28 days | Publications | |||||||||
| Glucoraphanin | Sulforaphane | Human | Plasma | Host metabolism | Gel Capsule: Oral formulation extracted from broccoli sprouts containing 200 µmol SFN | Extract | 17 | Patients with with skin melanoma; 5M; 12F; Age= 22-66 years old | 200 µmol SFN | Multiple | 28 days | Publications | |||||||||
| Glucoraphanin | Sulforaphane | Human | Plasma | Host metabolism | Gel Capsule: Oral formulation extracted from broccoli sprouts containing 50 µmol SFN | Extract | 17 | Patients with with skin melanoma; 5M; 12F; Age= 22-66 years old | 50 µmol SFN | Multiple | 28 days | Publications |