Intervention Studies for the metabolite 3'-O-Methyl-(-)-epicatechin 5-O-sulfate with food phytochemical (-)-Epicatechin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (-)-Epicatechin | 3'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma; Urine | Host metabolism | 250 mL of hot milk + 10 g cocoa powder | Food | 9 | Healthy; Age=20-43; BMI=24.7±2.7 kg/m2 | 45 µmol | Single | 1,3±0,2 (SEM) | 50±8 (SEM) | 125 | (0-8h) | 1,90±0,3 (SEM) | 3,608888889 | 1624±217 nmol (SEM) ((0-24h)) | Publications | |||
| (-)-Epicatechin | 3'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma; Urine | Host metabolism | 250 mL of water + 10 g cocoa powder | Food | 9 | Healthy; Age=20-43; BMI=24.7±2.7 kg/m2 | 45 µmol | Single | 1±0,2 (SEM) | 60±8 (SEM) | 123 | (0-8h) | 2,30±0,3 (SEM) | 6,135555556 | 2761±423 nmol (SEM) ((0-24h)) | Publications | |||
| (-)-Epicatechin | 3'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma; Urine | Host metabolism | 50 mL of solution + 60 mg of 14C-Epicatechin | Pure compound | 8 | Healthy; 8 M; Age=31±3; BMI=24.5±3.3 kg/m2 | 207 µmol | Single | 0,9±0,1 (SEM) | 240±24 (SEM) | 915 | (0-24h) | 1,60±0,1 (SEM) | 4,637681159 | 9.6±1,2 µmol (SEM) ((0-48h)) | Publications | |||
| (-)-Epicatechin | 3'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma; Urine | Host metabolism | 100 g of 70 % dark chocolate | Food | 5 | Healthy; Age=23.4±3.3 y; BMI=22±2 kg/m2 | 154 mg | Single | 3,6±0,2 (SEM) | 153±43 (SEM) | 679 | (0-24h) | 2,10±0,6 (SEM) | 3,2 | 14.1±3,88 µmol (SEM) ((0-24h)) | Publications |