Intervention Studies for the metabolite Curcumin with food phytochemical Curcumin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Curcumin | Curcumin | Human | Plasma | Unchanged | capsules of Theracurmin ® Triple (600 mg) | pure compound | 4 | 180 mg | Single | 2±(1-6) (IR) | 2,1 | 9,8 | (0-24h) | Publications | |||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | standard curcuminoids 95% (6 capsules) with 240 ml of water | pure compound | 12 | Healthy, M, age 32.08 ± 6.37 y, BMI 21.89±2.52 kg/m2 | 3 g | Single | 86,41 | 206,62 | (0-24h) | Publications | |||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | lipidic formulation of curcumin (CRM-LF) (750 mg) | pure compound | 12 | Healthy, M, age 26.45±5.02 y | 746.25 mg | Single | 0,6±0,05 (SEM) | 183,35±37,54 (SEM) | 231,31 | (0-24h) | 12,85±4,57 (SEM) | Publications | |||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | capsule of reference curcumin | pure compound | 12 | Healthy, M, age 18-45 y, BMI 18.5-30 kg/m2 | 500 mg | Single | 3,6±0,651 (SD) | 43,1±16,733 (SD) | 165,7 | (0-8h) | Publications | ||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | capsules of Solid lipid curcumin particle (SLCP) (650 mg) with water | extract | 6 | Healthy, M, 18-40 y, Indian | 162,5 mg | single | 2,4±0,44 (SD) | 22,43±1,92 (SEM) | 95,26 | (0-8h) | 7,46±2,43 (SEM) | Publications | |||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | 500 mg of Cureit™ in capsule with 240 mL water | pure compound | 15 | Healthy, BMI 18.5-24.9 kg/m2 | 232,5 mg | Single | 4 | 74,31 | 527,1 | (0-24h) | 1,681 | Publications | |||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | combination of Boswellia serrata extract, curcumin, pine bark extract and methylsulfonylmethane | pure compound | 4 | 180 mg | Single | 2±(1-8) (IR) | 1,7±(1.2,2.4) (IR) | 7,8 | (0-24h) | Publications | |||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | bioavailable curcumin formulation Curene ® (6 capsules) with 240 of water | pure compound | 12 | Healthy, M, age 32.08 ± 6.37 y, BMI 21.89±2.52 kg/m2 | 3 g | Single | 1545,83±672,92 (SD) | 6302,85 | (0-24h) | Publications | |||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | curcumin formulation containing turmeric volatile oil (CP-01) (6 capsules) with 240 ml of water | pure compound | 12 | Healthy, M, age 32.08 ± 6.37 y, BMI 21.89±2.52 kg/m2 | 3 g | Single | 190,29±111,22 (SD) | 445,05 | (0-24h) | Publications | |||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | capsule curcumin formulation (Cureit) | pure compound | 12 | Healthy, M, age 18-45 y, BMI 18.5-30 kg/m2 | 500 mg | Single | 4,2±0,621 (SD) | 434,25±256,605 (SD) | 904 | (0-8h) | Publications | ||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | liquid droplet micromicellar formulation (400 mg) | pure compound | 12 | Healthy, 6 M/6 F, age M (28.7 ± 7.7 y), age F (29.8 ± 6.7 y). BMI M (24.8 ± 3.1 kg/m2), BMI F (23.6 ± 3.4 kg/m2) | 76 mg | Single | 3,8±2,38 (SEM) | 2,0 | 1,6 | Publications | |||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | unformulated 95% curcumin capsules (400 mg) | pure compound | 12 | Healthy, 6 M/6 F, age M (28.7 ± 7.7 y), age F (29.8 ± 6.7 y). BMI M (24.8 ± 3.1 kg/m2), BMI F (23.6 ± 3.4 kg/m2) | 380 mg | Single | 4±1,67 (SEM) | 0,3 | 5,5 | Publications | |||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | curcumin powder + 150 mL water + 20 mg piperine | pure compound | 8 | Healthy, M, age 20-26 y | 2 g | Single | 0,69±0,07 (SEM) | 0,18±0,03 (SEM) | 0,08 | (0-inf) | 0,41±0,17 (SEM) | Publications | |||||
| Curcumin | Curcumin | Human | Serum | Unchanged | bread + free curcumin (1g) | food | 10 | Healthy, age 31 ± 2 y; BMI 23.5 ± 1.2 kg/m2 | 3000 µmol | Single | 0,5 | 1,44±0,53 (SEM) | 1,45 | (0-6h) | Publications | ||||||
| Curcumin | Curcumin | Human | Serum | Unchanged | bread + encapsulated curcumin (1g) | food | 10 | Healthy, age 31 ± 2 y; BMI 23.5 ± 1.2 kg/m2 | 3000 µmol | Single | 1 | 0,28±0,01 (SEM) | 0,21 | (0-6h) | Publications | ||||||
| Curcumin | Curcumin | Human | Serum | Unchanged | bread + encapsulated curcumin (1g) + polyphenols | food | 10 | Healthy, age 31 ± 2 y; BMI 23.5 ± 1.2 kg/m2 | 3000 µmol | Single | 6 | 1,12±0,66 (SEM) | 4,08 | (0-6h) | Publications | ||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | capsules of 95% curcuminoids extract (650 mg) with water | extract | 6 | Healthy, M, 18-40 y, Indian | 390 mg | single | 1 | Publications | |||||||||
| Curcumin | Curcumin | Human | Plasma | Unchanged | curcumin powder + 150 mL water | pure compound | 8 | Healthy, M, age 20-26 y | 2 g | Single | 0.006±0.005 (SEM) | 0.004 |