Intervention Studies for the metabolite 4'-O-Methyl-(-)-epicatechin 5-O-sulfate with food phytochemical (-)-Epicatechin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (-)-Epicatechin | 4'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma; Urine | Host metabolism | 50 mL of solution + 60 mg of 14C-Epicatechin | Pure compound | 8 | Healthy; 8 M; Age=31±3; BMI=24.5±3.3 kg/m2 | 207 µmol | Single | 0,9±0,1 (SEM) | 53±14 (SEM) | 128 | (0-24h) | 1,40±0,3 (SEM) | 0,5314009662 | 1.1±0,3 µmol (SEM) ((0-48h)) | Publications | |||
| (-)-Epicatechin | 4'-O-Methyl-(-)-epicatechin 5-O-sulfate | Human | Plasma; Urine | Host metabolism | 100 g of 70 % dark chocolate | Food | 5 | Healthy; Age=23.4±3.3 y; BMI=22±2 kg/m2 | 154 mg | Single | 3,8±0,2 (SEM) | 18±6 (SEM) | 94 | (0-24h) | 2,30±0,5 (SEM) | 0,3 | 1.37±0,34 µmol (SEM) ((0-24h)) | Publications |