Intervention Studies for the metabolite 5-(3',4'-dihydroxyphenyl)-γ-valerolactone with food phytochemical Green tea Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Green tea Flavan-3-ols | 5-(3',4'-dihydroxyphenyl)-γ-valerolactone | Human | Urine | Gut microbiota metabolite | Tablets | Extract | 11 | Healthy; 9 F; 2 M; Age=28±6 y; BMI=21.8±1.6 kg/m2 | 9972 µmol | Multiple | 4 weeks (6 doses daily) | 0,3770557561 | 37.6±4,4 µmol (SEM) ((0-24h)) | Publications | |||||||
| Green tea Flavan-3-ols | 5-(3',4'-dihydroxyphenyl)-γ-valerolactone | Human | Plasma | Gut microbiota metabolite | 330 mL of drink | Extract | 12 | Healthy; 12 M; Age=21±2 y; BMI=24.2±1.9 kg/m2 | 1118.4 mg | Multiple | 1 day (1 dose morning + 1 dose evening) | 1,2±0,3 (SD) | 110 | (0-3h) | Publications | ||||||
| Green tea Flavan-3-ols | 5-(3',4'-dihydroxyphenyl)-γ-valerolactone | Human | Plasma | Gut microbiota metabolite | 330 mL of drink | Extract | 13 | Healthy; 13 M; Age=22±5 y; BMI=24.3±3.0 kg/m2 | 1118.4 mg | Multiple | 7 days (1 dose morning + 1 dose evening) | 0,58±0,12 (SD) | 70 | (0-3h) | Publications |