Intervention Studies for the metabolite 5-(Hydroxyphenyl)-γ-valerolactone-glucuronide with food phytochemical Green tea Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | Tablets | Extract | 11 | Healthy; 9 F; 2 M; Age=28±6 y; BMI=21.8±1.6 kg/m2 | 9972 µmol | Multiple | 4 weeks (6 doses daily) | 5,227637385 | 521.3±91,2 µmol (SEM) ((0-24h)) | Publications | |||||||
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 5 cups green tea + 50 mg vit C | Food | 50 | Healthy; Age=18-65 y; Caucasians | 1053,883432 µmol | Single | 2,087517399 | 22±7 µmol (SD) ((0-24h)) | Publications | ||||||||
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 5 cups green tea + 50 mg vit C | Food | 50 | Healthy; Age=18-65 y; Caucasians | 1053,883432 µmol | Multiple | 6 weeks | 8,539843905 | 90±60 µmol (SD) ((0-24h)) | Publications | |||||||
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 5 cups green tea + 50 mg vit C | Food | 50 | Healthy; Age=18-65 y; Caucasians | 1053,883432 µmol | Multiple | 12 weeks | 1,89774309 | 20±4 µmol (SD) ((0-24h)) | Publications | |||||||
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-glucuronide | Human | Urine | Gut microbiota metabolite | 400 mL of green tea | Food | 20 | Healthy; Age=26±5 y; BMI=23±3 kg/m2 | 403,9 µmol | Single | 4,83 | 19.52±12,1 µmol (SD) ((0-24h)) | Publications |