Intervention Studies for the metabolite 5-(Hydroxyphenyl)-γ-valerolactone-methoxy-sulfate with food phytochemical Green tea Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-methoxy-sulfate | Human | Urine | Host-gut microbiota co-metabolite | Tablets | Extract | 11 | Healthy; 9 F; 2 M; Age=28±6 y; BMI=21.8±1.6 kg/m2 | 9972 µmol | Multiple | 4 weeks (6 doses daily) | 0,9596871239 | 95.7±36,5 µmol (SEM) ((0-24h)) | Publications | |||||||
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-methoxy-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 5 cups green tea + 50 mg vit C | Food | 50 | Healthy; Age=18-65 y; Caucasians | 1053,883432 µmol | Single | 14,23307318 | 150±60 µmol (SD) ((0-24h)) | Publications | ||||||||
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-methoxy-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 5 cups green tea + 50 mg vit C | Food | 50 | Healthy; Age=18-65 y; Caucasians | 1053,883432 µmol | Multiple | 6 weeks | 13,28420163 | 140±50 µmol (SD) ((0-24h)) | Publications | |||||||
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-methoxy-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 5 cups green tea + 50 mg vit C | Food | 50 | Healthy; Age=18-65 y; Caucasians | 1053,883432 µmol | Multiple | 12 weeks | 7,59097236 | 80±20 µmol (SD) ((0-24h)) | Publications | |||||||
| Green tea Flavan-3-ols | 5-(Hydroxyphenyl)-γ-valerolactone-methoxy-sulfate | Human | Urine | Gut microbiota metabolite | 400 mL of green tea | Food | 20 | Healthy; Age=26±5 y; BMI=23±3 kg/m2 | 403,9 µmol | Single | 4,72 | 19.05±22,43 µmol (SD) ((0-24h)) | Publications |