Intervention Studies for the metabolite Methoxy-(epi)catechin-sulfate with food phytochemical Red Grape pomace Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Red Grape pomace Flavan-3-ols | Methoxy-(epi)catechin-sulfate | Human | Plasma; Urine | Host metabolism | 250 mL of red grape pomace aqueous extract | Extract | 10 | Healthy; 10 M; Age=26±2 y; BMI=27±3 kg/m2 | 983.47 µmol | Single | 2,7±0,8 (SEM) | 12,6±1,9 (SEM) | 53,1 | (0-24h) | 8,10±1,3 (SEM) | 0,03863869767 | 0.38±0,07 µmol (SEM) ((0-48h)) | Publications | |||
| Red Grape pomace Flavan-3-ols | Methoxy-(epi)catechin-sulfate | Human | Urine | Host metabolism | 250 mL of red grape pomace aqueous extract | Extract | 10 | Healthy; 10 M; Age=26±2 y; BMI=27±3 kg/m2 | 983.47 µmol | Single | 0,201327951 | 1.98±0,32 µmol (SEM) ((0-48h)) | Publications | ||||||||
| Red Grape pomace Flavan-3-ols | Methoxy-(epi)catechin-sulfate | Human | Plasma; Urine | Host metabolism | 100 mL of dealcoholised red wine + grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 14±9,45 (SD) | 1,37 | (0-24h) | 6,871100999 | 2.63±1,24 µmol (SD) ((0-24h)) | Publications | |||||
| Red Grape pomace Flavan-3-ols | Methoxy-(epi)catechin-sulfate | Human | Plasma; Urine | Host metabolism | 100 mL of dealcoholised red wine + grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 25,9±12,1 (SD) | 5,47 | (0-24h) | 13,6115727 | 5.21±3,46 µmol (SD) ((0-24h)) | Publications | |||||
| Red Grape pomace Flavan-3-ols | Methoxy-(epi)catechin-sulfate | Human | Plasma; Urine | Host metabolism | 100 mL of dealcoholised red wine + encapsulated grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 10,8±9,62 (SD) | 1,08 | (0-24h) | 9,692693805 | 3.71±1,88 µmol (SD) ((0-24h)) | Publications | |||||
| Red Grape pomace Flavan-3-ols | Methoxy-(epi)catechin-sulfate | Human | Plasma; Urine | Host metabolism | 100 mL of dealcoholised red wine + encapsulated grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 15,2±16,7 (SD) | 2,36 | (0-24h) | 20,53492542 | 7.86±3,06 µmol (SD) ((0-24h)) | Publications |