Intervention Studies for the metabolite (Epi)catechin O-glucuronide with food phytochemical Red Grape pomace Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Red Grape pomace Flavan-3-ols | (Epi)catechin O-glucuronide | Human | Plasma; Urine | Host metabolism | 250 mL of red grape pomace aqueous extract | Extract | 10 | Healthy; 10 M; Age=26±2 y; BMI=27±3 kg/m2 | 983.47 µmol | Single | 1,7±0,3 (SEM) | 135,5±14,2 (SEM) | 459,9 | (0-24h) | 2,30±0,4 (SEM) | 0,176924563 | 1.74±0,15 µmol (SEM) ((0-48h)) | Publications | |||
| Red Grape pomace Flavan-3-ols | (Epi)catechin O-glucuronide | Human | Plasma; Urine | Host metabolism | 100 mL of dealcoholised red wine + grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 9,96±5,21 (SD) | 0,71 | (0-24h) | 1,724306715 | 0.66±0,47 µmol (SD) ((0-24h)) | Publications | |||||
| Red Grape pomace Flavan-3-ols | (Epi)catechin O-glucuronide | Human | Plasma; Urine | Host metabolism | 100 mL of dealcoholised red wine + grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 59,1±12,9 (SD) | 13,9 | (0-24h) | 15,67551559 | 6.00±4,55 µmol (SD) ((0-24h)) | Publications | |||||
| Red Grape pomace Flavan-3-ols | (Epi)catechin O-glucuronide | Human | Plasma; Urine | Host metabolism | 100 mL of dealcoholised red wine + encapsulated grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 4,64±1,34 (SD) | 0,06 | (0-24h) | 2,429704916 | 0.93±0,7 µmol (SD) ((0-24h)) | Publications | |||||
| Red Grape pomace Flavan-3-ols | (Epi)catechin O-glucuronide | Human | Plasma; Urine | Host metabolism | 100 mL of dealcoholised red wine + encapsulated grape pomace extract (1:3) | Extract | 12 | Healthy; 6 F; 6 M; Age=19-50; BMI for M=26.4±3.5 kg/m2; BMI for F=26.1±3.8 kg/m2 | 16,4 mg | Single | 63,4±28,9 (SD) | 12,4 | (0-24h) | 21,08356847 | 8.07±4,48 µmol (SD) ((0-24h)) | Publications |