Intervention Studies for the metabolite 3′-Methoxy-(−)-epicatechin-5′-glucuronide with food phytochemical (-)-Epicatechin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (-)-Epicatechin | 3′-Methoxy-(−)-epicatechin-5′-glucuronide | Human | Urine | Host metabolism | 25 g of flavanol-rich cocoa + 200 mL of milk | Food | 13 | Healthy; 3 M; 10 F; Age M=26.67±3.21 y; BMI M=22.47±2.97 kg/m2. Age F=32.60±9.85 y. BMI F=23.36±3.73 kg/m2 | 235.1 µmol | Single | 0,05146746066 | 0.121±0,036 µmol (SD) ((0-24h)) | Publications | ||||||||
| (-)-Epicatechin | 3′-Methoxy-(−)-epicatechin-5′-glucuronide | Human | plasma | Host metabolism | 50 mL of solution + 60 mg of 14C-Epicatechin | Pure compound | 8 | Healthy; 8 M; Age=31±3; BMI=24.5±3.3 kg/m2 | 207 µmol | Single | 0,8±0,2 (SEM) | 23±5 (SEM) | 25 | (0-24h) | 1,30±0,2 (SEM) | Publications |