Intervention Studies for the metabolite (-)-Epigallocatechin with food phytochemical (-)-Epigallocatechin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (-)-Epigallocatechin | (-)-Epigallocatechin | Human | Plasma | Unchanged | 330 mL of drink | Extract | 12 | Healthy; 12 M; Age=21±2 y; BMI=24.2±1.9 kg/m2 | 1118.4 mg | Multiple | 1 day (1 dose morning + 1 dose evening) | 20±6 (SD) | 2604 | (0-3h) | Publications | ||||||
| (-)-Epigallocatechin | (-)-Epigallocatechin | Human | Plasma | Unchanged | 330 mL of drink | Extract | 13 | Healthy; 13 M; Age=22±5 y; BMI=24.3±3.0 kg/m2 | 1118.4 mg | Multiple | 7 days (1 dose morning + 1 dose evening) | 19±6 (SD) | 2499 | (0-3h) | Publications | ||||||
| (-)-Epigallocatechin | (-)-Epigallocatechin | Human | Plasma | Unchanged | 375 mg of Sunphenon BG-5 + 200 mL of water | Extract | 5 | Healthy; 5 F; Age=22 y; BMI=16.2–20.2 kg/m2 | 714 µmol | Single | 1,5 | 0,7 | Publications | ||||||||
| (-)-Epigallocatechin | (-)-Epigallocatechin | Human | Plasma | Unchanged | 375 mg of Sunphenon BG-5 + 200 mL of water + 20 g chocolate | Extract | 5 | Healthy; 5 F; Age=22 y; BMI=16.2–20.2 kg/m2 | 729 µmol | Single | 1,5 | 0,8 | Publications | ||||||||
| (-)-Epigallocatechin | (-)-Epigallocatechin | Human | Urine | Unchanged | 340 mL canned green tea | Food | 1 | Healthy; F; Age=32 y | 176,324 mg | Single | 3,7 | 0.8 mg ((0-38h)) | Publications | ||||||||
| (-)-Epigallocatechin | (-)-Epigallocatechin | Human | Plasma | Unchanged | capsules of Polyphenon E | Extract | 5 | Healthy; Age ≥ 30 y | 804 mg | Single | 2 | 15 | Publications |