Intervention Studies for the metabolite (Epi)catechin O-glucuronide with food phytochemical Apple Flavan-3-ols
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Apple Flavan-3-ols | (Epi)catechin O-glucuronide | Human | Urine | Host metabolism | Capsules of low dose monomers | Extract | 42 | Healthy; 15 M; 27 F; Age= ≥ 50 y | 467 µmol | Multiple | 28 days (1 dose daily) | 4,111349036 | 19.2±(10.2-35.1) µmol (IR) ((0-24h)) | Publications | |||||||
| Apple Flavan-3-ols | (Epi)catechin O-glucuronide | Human | Urine | Host metabolism | Capsules of high dose monomers | Extract | 42 | Healthy; 15 M; 27 F; Age= ≥ 50 y | 934 µmol | Multiple | 28 days (1 dose daily) | 4,903640257 | 45.8±(29.3-77.8) µmol (IR) ((0-24h)) | Publications | |||||||
| Apple Flavan-3-ols | (Epi)catechin O-glucuronide | Human | Urine | Host metabolism | Capsules of oligomeric procyanidins | Extract | 42 | Healthy; 15 M; 27 F; Age= ≥ 50 y | 472 µmol | Multiple | 28 days (1 dose daily) | 0,02118644068 | 0.1±(0.1-0.4) µmol (IR) ((0-24h)) | Publications |