Intervention Studies for the metabolite Sulforaphane-N-acetyl-L-cysteine with food phytochemical Glucoraphanin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glucoraphanin | Sulforaphane-N-acetyl-L-cysteine | Human | Urine | Host metabolism | Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin | Food | 14 | Healthy women; age= 27-36 Y | 20g of broccoli sproutscontaining 64 µmol of glucoraphanin | Multiple | 7 days | Publications | |||||||||
| Glucoraphanin | Sulforaphane-N-acetyl-L-cysteine | Human | Urine | Host metabolism | Broccoli cooked sous vide in boiling water at 100 °C for 20 min (inactivated myrosinase), then pureed with 100 ml water (1.06 ± 0.18 μmol g−1 dry weight) | Food | 12 | Healthy, Age=18- 64 Y | 200 g | Single | 24 h | 9.8±5,1 µmol (0-24h) | Publications | ||||||||
| Glucoraphanin | Sulforaphane-N-acetyl-L-cysteine | Human | Urine | Host metabolism | Broccoli cooked sous vide in boiling water at 100 °C for 20 min (inactivated myrosinase), then pureed with 100 ml water and 1 g brown powdered mustard seed added (8.58 ± 0.33 μmol g−1 dry weight) | Food | 12 | Healthy, Age=18- 64 Y | 200 g | Single | 24 h | 44.7±33,9 µmol (0-24h) | Publications | ||||||||
| Glucoraphanin | Sulforaphane-N-acetyl-L-cysteine | Human | Plasma; Urine | Host metabolism | Broccoli (200g) with 20 g of raw daikon radish | Food | 18 | Healthy; 8M; 10W; Age=37–65 years; BMI = 19-37 kg/m² | 200 g | Multiple | 17 days once a day | 1-3 | Publications | ||||||||
| Glucoraphanin | Sulforaphane-N-acetyl-L-cysteine | Human | Plasma; Urine | Host metabolism | 200 g of uncooked broccoli florets | Food | 6 | Healthy; Age=28-67 Y; BMI= 25.3-28.1Kg/m² | 200 g uncooked broccoli florets | Single | Publications | ||||||||||
| Glucoraphanin | Sulforaphane-N-acetyl-L-cysteine | Human | Plasma | Host metabolism | Myrosinase-activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours. | Extract | 6 | Healthy; F; Age= 18-35Y | 32 mg sulforaphane | Single | 2 (SEM) | 66 | 315,5 | 0-8h | Publications | ||||||
| Glucoraphanin | Sulforaphane-N-acetyl-L-cysteine | Human | Plasma | Host metabolism | Myrosinase-non activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours. | Extract | 6 | Healthy; F; Age= 18-35Y | 32 mg sulforaphane | Single | 2 (SEM) | 48 | 195,5 | 0-8h | Publications | ||||||
| Glucoraphanin | Sulforaphane-N-acetyl-L-cysteine | Human | Plasma; Urine | Host metabolism | 200 g of blanched and frozen broccoli (100g in breakfast and 100g in the dinner) ( 147.6μmol ofglucoraphanin and 3.6μmol of glucoerucin). | Food | 18 | Healthy;9M;8F;Age=40-70Y | 200g (the day before the study treated group eat only 100g and the day of the study all volunteers treated and non-treated eat 200g) | Multiple | 17 days | 4 | 24h | 38 | Publications | ||||||
| Glucoraphanin | Sulforaphane-N-acetyl-L-cysteine | Human | Urine | Host metabolism | The treatment were applied during 10 weeks (70 days) and samples were taken on day 0 and 70 and after the treatment on day 90 and 160) | Food | 40 | Obese; Age= 35-55 Y; BMI= 24.9- 29.9 kg/m² | 30 g per day | Multiple | 70 days | 0.193 µM (day 0); 2.301 µM(day 70); 0.023 µM (day 90); 0.094 µM (day 160)±0-0.41 µM (day 0); 1.85-2.75 µM(day 70); 0.01-0.04 µM (day 90); 0.0-0.19 µM (day 160) (CI) | Publications |