Intervention Studies for the metabolite Sulforaphane-cysteine with food phytochemical Glucoraphanin

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Glucoraphanin		Sulforaphane-cysteine	Human	Urine	Host metabolism	Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin	Food	14	Healthy women; age= 27-36 Y	Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin	Multiple	7 days								Publications
	Glucoraphanin		Sulforaphane-cysteine	Human	Plasma; Urine	Host metabolism	Broccoli (200g) with 20 g of raw daikon radish	Food	18	Healthy; 8M; 10W; Age=37–65 years; BMI = 19-37 kg/m²	200 g	Multiple	17 days once a day	1-3							Publications
	Glucoraphanin		Sulforaphane-cysteine	Human	Plasma; Urine	Host metabolism	200 g of uncooked broccoli florets	Food	6	Healthy; Age=28-67 Y; BMI= 25.3-28.1Kg/m²	200 g uncooked broccoli florets	Single									Publications
	Glucoraphanin		Sulforaphane-cysteine	Human	Plasma	Host metabolism	Myrosinase-activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours.	Extract	6	Healthy; F; Age= 18-35Y	32 mg sulforaphane	Single		2 (SEM)	160	444,3	0-8h				Publications
	Glucoraphanin		Sulforaphane-cysteine	Human	Plasma	Host metabolism	Myrosinase-non activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours.	Extract	6	Healthy; F; Age= 18-35Y	32 mg sulforaphane	Single		0.5 (SEM)	100	217,9	0-8h				Publications
	Glucoraphanin		Sulforaphane-cysteine	Human	Urine	Host metabolism	Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85	Food	21	Obese ;21 M; Age=40-60 Y; BMI= 24.9-29.9 kg/m²	30 g / day	Multiple	85 days							0.0248 nmol/mg creatinine (day 0); 0.466 nmol/mg creatinine (day 35); 0.1199 nmol/mg creatinine (day 50); 0.0214 nmol/mg creatinine (day 85)±0.002-0.0612 nmol/mg creatinine (day 0); 0.3304-0.6037nmol/mg creatinine (day 35);0.0018-0.1599nmol/mg creatinine (day 50); 0.0025-0.0285 nmol/mg creatinine (day 85) (CI)	Publications
	Glucoraphanin		Sulforaphane-cysteine	Human	Urine	Host metabolism	The treatment were applied during 10 weeks (70 days) and samples were taken on day 0 and 70 and after the treatment on day 90 and 160)	Food	40	Obese; Age= 35-55 Y; BMI= 24.9- 29.9 kg/m²	30 g per day	Multiple	70 days							0.116 µM (day 0); 0.8 µM(day 70); 0.078 µM (day 90); 0.081 µM (day 160)±0-0.26 µM (day 0); 0.57-1.03 µM(day 70); 0.0-0.22 µM (day 90); 0.0-0.19 µM (day 160) (CI)	Publications
	Glucoraphanin		Sulforaphane-cysteine	Human	Urine	Host metabolism	Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85	Food	19	Obese;19 non-menauposal F; Age=40-60 Y; BMI= 24.9-29.9 kg/m²	30 g / day	Multiple	85 days							0.0749 mol/mg creatinine (day 0); 0.3727 nmol/mg creatinine (day 35); 0.0046nmol/mg creatinine (day 50);0.004 nmol/mg creatinine (day 85)±0.0035-0.0977 nmol/mg creatinine (day 0); 0.0301-0.6345 nmol/mg creatinine (day 35); 0.0035-0.0058 nmol/mg creatinine (day 50); 0.0033-0.0391 nmol/mg creatinine (day 85) (CI)	Publications
	Glucoraphanin		Sulforaphane-cysteine	Human	Urine	Host metabolism	Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85	Food	19	Obese;19 post-menauposal F; Age=40-60 Y; BMI= 24.9-29.9 kg/m²	30 g / day	Multiple	85 days							0.0656 nmol/mg creatinine (day 0);1.8191 nmol/mg creatinine (day 35);0.0135 nmol/mg creatinine (day 50); 0.004 nmol/mg creatinine (day 85)±0.0044-0.0876 nmol/mg creatinine (day 0); 0.116-2.2411 nmol/mg creatinine (day 35);0.0022-0.0179 nmol/mg creatinine (day 50); 0.0029-0.0048 nmol/mg creatinine (day 85) (CI)	Publications

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