Intervention Studies for the metabolite Sulforaphane-cysteine with food phytochemical Glucoraphanin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glucoraphanin | Sulforaphane-cysteine | Human | Urine | Host metabolism | Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin | Food | 14 | Healthy women; age= 27-36 Y | Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin | Multiple | 7 days | Publications | |||||||||
| Glucoraphanin | Sulforaphane-cysteine | Human | Plasma; Urine | Host metabolism | Broccoli (200g) with 20 g of raw daikon radish | Food | 18 | Healthy; 8M; 10W; Age=37–65 years; BMI = 19-37 kg/m² | 200 g | Multiple | 17 days once a day | 1-3 | Publications | ||||||||
| Glucoraphanin | Sulforaphane-cysteine | Human | Plasma; Urine | Host metabolism | 200 g of uncooked broccoli florets | Food | 6 | Healthy; Age=28-67 Y; BMI= 25.3-28.1Kg/m² | 200 g uncooked broccoli florets | Single | Publications | ||||||||||
| Glucoraphanin | Sulforaphane-cysteine | Human | Plasma | Host metabolism | Myrosinase-activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours. | Extract | 6 | Healthy; F; Age= 18-35Y | 32 mg sulforaphane | Single | 2 (SEM) | 160 | 444,3 | 0-8h | Publications | ||||||
| Glucoraphanin | Sulforaphane-cysteine | Human | Plasma | Host metabolism | Myrosinase-non activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours. | Extract | 6 | Healthy; F; Age= 18-35Y | 32 mg sulforaphane | Single | 0.5 (SEM) | 100 | 217,9 | 0-8h | Publications | ||||||
| Glucoraphanin | Sulforaphane-cysteine | Human | Urine | Host metabolism | Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85 | Food | 21 | Obese ;21 M; Age=40-60 Y; BMI= 24.9-29.9 kg/m² | 30 g / day | Multiple | 85 days | 0.0248 nmol/mg creatinine (day 0); 0.466 nmol/mg creatinine (day 35); 0.1199 nmol/mg creatinine (day 50); 0.0214 nmol/mg creatinine (day 85)±0.002-0.0612 nmol/mg creatinine (day 0); 0.3304-0.6037nmol/mg creatinine (day 35);0.0018-0.1599nmol/mg creatinine (day 50); 0.0025-0.0285 nmol/mg creatinine (day 85) (CI) | Publications | ||||||||
| Glucoraphanin | Sulforaphane-cysteine | Human | Urine | Host metabolism | The treatment were applied during 10 weeks (70 days) and samples were taken on day 0 and 70 and after the treatment on day 90 and 160) | Food | 40 | Obese; Age= 35-55 Y; BMI= 24.9- 29.9 kg/m² | 30 g per day | Multiple | 70 days | 0.116 µM (day 0); 0.8 µM(day 70); 0.078 µM (day 90); 0.081 µM (day 160)±0-0.26 µM (day 0); 0.57-1.03 µM(day 70); 0.0-0.22 µM (day 90); 0.0-0.19 µM (day 160) (CI) | Publications | ||||||||
| Glucoraphanin | Sulforaphane-cysteine | Human | Urine | Host metabolism | Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85 | Food | 19 | Obese;19 non-menauposal F; Age=40-60 Y; BMI= 24.9-29.9 kg/m² | 30 g / day | Multiple | 85 days | 0.0749 mol/mg creatinine (day 0); 0.3727 nmol/mg creatinine (day 35); 0.0046nmol/mg creatinine (day 50);0.004 nmol/mg creatinine (day 85)±0.0035-0.0977 nmol/mg creatinine (day 0); 0.0301-0.6345 nmol/mg creatinine (day 35); 0.0035-0.0058 nmol/mg creatinine (day 50); 0.0033-0.0391 nmol/mg creatinine (day 85) (CI) | Publications | ||||||||
| Glucoraphanin | Sulforaphane-cysteine | Human | Urine | Host metabolism | Broccoli sprouts; the treatment were applied during 5 weeks (35 days) and samples were taken on day 0 and 35 and after the treatment on day 50 and 85 | Food | 19 | Obese;19 post-menauposal F; Age=40-60 Y; BMI= 24.9-29.9 kg/m² | 30 g / day | Multiple | 85 days | 0.0656 nmol/mg creatinine (day 0);1.8191 nmol/mg creatinine (day 35);0.0135 nmol/mg creatinine (day 50); 0.004 nmol/mg creatinine (day 85)±0.0044-0.0876 nmol/mg creatinine (day 0); 0.116-2.2411 nmol/mg creatinine (day 35);0.0022-0.0179 nmol/mg creatinine (day 50); 0.0029-0.0048 nmol/mg creatinine (day 85) (CI) | Publications |