Intervention Studies for the metabolite Sulforaphane-glutathione with food phytochemical Glucoraphanin
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glucoraphanin | Sulforaphane-glutathione | Human | Urine | Host metabolism | Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin | Food | 14 | Healthy women; age= 27-36 Y | Broccoli sprouts (20 g) containing 64 µmol of glucoraphanin | Multiple | 7 days | Publications | |||||||||
| Glucoraphanin | Sulforaphane-glutathione | Human | Plasma; Urine | Host metabolism | Broccoli (200g) with 20 g of raw daikon radish | Food | 18 | Healthy; 8M; 10W; Age=37–65 years; BMI = 19-37 kg/m² | 200 g | Multiple | 17 days once a day | 1-3 | Publications | ||||||||
| Glucoraphanin | Sulforaphane-glutathione | Human | Plasma; Urine | Host metabolism | 200 g of uncooked broccoli florets | Food | 6 | Healthy; Age=28-67 Y; BMI= 25.3-28.1Kg/m² | 200 g uncooked broccoli florets | Single | Publications | ||||||||||
| Glucoraphanin | Sulforaphane-glutathione | Human | Plasma | Host metabolism | Myrosinase-activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours. | Extract | 6 | Healthy; F; Age= 18-35Y | 32 mg sulforaphane | Single | 2 (SEM) | 280 | 845,7 | 0-8h | Publications | ||||||
| Glucoraphanin | Sulforaphane-glutathione | Human | Plasma | Host metabolism | Myrosinase-non activated broccoli seed extract (BroccoMax®). Blood samples were taken at 0, 0.5, 1, 2, 4 and 8 hours. | Extract | 6 | Healthy; F; Age= 18-35Y | 32 mg sulforaphane | Single | 0.5 (SEM) | 140 | 443,9 | 0-8h | Publications | ||||||
| Glucoraphanin | Sulforaphane-glutathione | Human | Plasma; Urine | Host metabolism | 200 g of blanched and frozen broccoli (100g in breakfast and 100g in the dinner) ( 147.6μmol ofglucoraphanin and 3.6μmol of glucoerucin). | Food | 18 | Healthy;9M;8F;Age=40-70Y | 200g (the day before the study treated group eat only 100g and the day of the study all volunteers treated and non-treated eat 200g) | Multiple | 17 days | 6 | 24h | 0 | Publications |