Intervention Studies for the metabolite Dihydrocaffeic acid with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Dihydrocaffeic acid | Human | Plasma | Gut microbiota metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 5,2±0,5 (SEM) | 41 (SEM) | 142 | (0-24h) | 1±0,4 (SEM) | Publications | |||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid | Human | Plasma | Gut microbiota metabolite | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 6,63 | 89 | 24010 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid | Human | Plasma | Gut microbiota metabolite | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,07 | 63 | 15994 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid | Human | Plasma | Gut microbiota metabolite | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,05 | 51 | 5466 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid | Human | Plasma | Gut microbiota metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 6±(4.0;6.0) (IR) | 49±(34;54) (IR) | 118 | (0-24h) | 0,7±(0.4;0.8) (IR) | Publications | |||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid | Human | Plasma | Gut microbiota metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 6±(6.0;6.0) (IR) | 56±(39;101) (IR) | 481 | (0-24h) | 3±(2.6;3.5) (IR) | Publications | |||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid | Human | Plasma | Gut microbiota metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 6±(6.0;7.5) (IR) | 72±(56;102) (IR) | 631 | (0-24h) | 2,7±(1.1;2.9) (IR) | Publications | |||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid | Human | Plasma; Urine | Gut microbiota metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 6 ± 1±1 (SD) | 0,03±0,01 (SD) | 0,12 | (0-12h) | 0,33 | 2.5µmol(0-24h)±0,5 (SD) (2.5µmol(0-24h)) | Publications |