Intervention Studies for the metabolite Ferulic acid-4'-O-glucuronide with food phytochemical Coffee Chlorogenic acids

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	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications

	Food Phytochemical		Metabolite	Species	Biofluids	Origin	Dietary Source Description	Dietary Source Classification	Total Number of Subjects	Description of Population	Ingested Amount	Single/Multiple Dose	Duration of the Study	Tmax (h)	Cmax (nM)	AUC (nM/h)	Time covered by AUC (h)	t 1/2 (h)	% of 24h Urinary Excretion	Excreted Amount & Time Interval	Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma	Host metabolism	3.6 g of ground coffee + 50 mL water	food	15	Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2	778,43 µmol	Single		1	25,78±2,13 (SEM)						Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma	Host metabolism	3.6 g of ground coffee + 50 mL water	food	15	Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2	214,15 µmol	Single		1	23,05±2,51 (SEM)						Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma	Host metabolism	200 mL of instant coffee beverage	food	14	Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians	48,03 µmol	Single		0,45	31	5939	(0-15h)				Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma	Host metabolism	200 mL of coffee + 2 bread rolls + honey	food	14	Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians	48,03 µmol	Single		1,50	30	7807	(0-15h)				Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma	Host metabolism	200 mL of coffee + 1 bread roll + peanut butter	food	14	Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians	48,03 µmol	Single		1,98	29	7273	(0-15h)				Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma	Host metabolism	350 mL of coffee (18.66 g of coffee)	food	13	Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y)	519,07 µmol	Single		0,75	0,302±0,18 (SD)						Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma; Urine	Host metabolism	250 mL of coffee (3.5 g of green-roasted coffee)	food	12	Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2)	760.6 μmol	Single		1,1±0,5 (SD)	0,011±0,004 (SD)	0,03	(0-12h)		0,30	2.3µmol(0-24h)±0,3 (SD) (2.3µmol(0-24h))	Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma; Urine	Host-gut microbiota co-metabolite	1 cup of coffee	food	21	Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2	204,90 µmol	Multiple	1 month (1 daily dose)	4,3±0,7 (SEM)	56,4±5,9 (SEM)	573,6	(0-24h)		4,79	9.81±0,58 µmol(0-24h) (SEM) (µmol(0-24h))	Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma; Urine	Host-gut microbiota co-metabolite	3 cups of coffee	food	21	Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2	614,60 µmol	Multiple	1 month (3 dose daily)	6,1±0,4 (SEM)	80,6±8,6 (SEM)	769,8	(0-24h)		2,74	16.84µmol(0-24h)±1,52 (SEM) (16.84µmol(0-24h))	Publications
	Coffee Chlorogenic acids		Ferulic acid-4'-O-glucuronide	Human	Plasma; Urine	Host-gut microbiota co-metabolite	1 cup of coffee + 2 cocoa products containing coffee	food	21	Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2	296,00 µmol	Multiple	1 month (2 dose daily)	4,9±0,6 (SEM)	52,2±6,2 (SEM)	447,2	(0-24h)		3,80	11.26µmol(0-24h)±1,01 (SEM) (11.26µmol(0-24h))	Publications

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