Intervention Studies for the metabolite Ferulic acid-4'-O-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 778,43 µmol | Single | 1 | 25,78±2,13 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 214,15 µmol | Single | 1 | 23,05±2,51 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma | Host metabolism | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 0,45 | 31 | 5939 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma | Host metabolism | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,50 | 30 | 7807 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma | Host metabolism | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,98 | 29 | 7273 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma | Host metabolism | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 0,75 | 0,302±0,18 (SD) | Publications | ||||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma; Urine | Host metabolism | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 1,1±0,5 (SD) | 0,011±0,004 (SD) | 0,03 | (0-12h) | 0,30 | 2.3µmol(0-24h)±0,3 (SD) (2.3µmol(0-24h)) | Publications | ||||
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 4,3±0,7 (SEM) | 56,4±5,9 (SEM) | 573,6 | (0-24h) | 4,79 | 9.81±0,58 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 6,1±0,4 (SEM) | 80,6±8,6 (SEM) | 769,8 | (0-24h) | 2,74 | 16.84µmol(0-24h)±1,52 (SEM) (16.84µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Ferulic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 4,9±0,6 (SEM) | 52,2±6,2 (SEM) | 447,2 | (0-24h) | 3,80 | 11.26µmol(0-24h)±1,01 (SEM) (11.26µmol(0-24h)) | Publications |