Intervention Studies for the metabolite Ferulic acid-4'-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 778,43 µmol | Single | 1 | 43,26±3,7 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 214,15 µmol | Single | 1 | 38,19±2,47 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host metabolism | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 0,37 | 37 | 3964 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host metabolism | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,13 | 26 | 5298 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host metabolism | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,18 | 29 | 5216 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host metabolism | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 1 | 0,226±0,113 (SD) | Publications | ||||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma; Urine | Host metabolism | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 0,7±0,2 (SD) | 0,02±0,01 (SD) | 0,03 | (0-12h) | 1,05 | 8µmol(0-24h)±1 (SD) (8µmol(0-24h)) | Publications | ||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma; Urine | Host metabolism | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 0,5±(0.5;0.5) (IR) | 65±(61;90) (IR) | 2,40 | 9.9µmol(0-24h)±(7.3;13.7) (IR) (9.9µmol(0-24h)) | Publications | ||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma; Urine | Host metabolism | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 0,5±(0.5;0.5) (IR) | 126±(111;195) (IR) | 2,30 | 14.4µmol(0-24h)±(12.3;26.7) (IR) (14.4µmol(0-24h)) | Publications | ||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma; Urine | Host metabolism | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 0,5±(0.5;0.5) (IR) | 68±(47;94) (IR) | 2,00 | 16.1µmol(0-24h)±(12.3;24.8) (IR) (16.1µmol(0-24h)) | Publications | ||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma; Urine | Host metabolism | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 0,6±0,1 (SEM) | 76±9 (SEM) | 467 | (0-24h) | 4,9±1 (SEM) | 2,69 | 11.1µmol(1-24h)±1,6 (SEM) (11.1µmol(1-24h)) | Publications | |||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 4±(4.0;4.0) (IR) | 33±(26;41) (IR) | 409 | (0-24h) | 3,6±(3.3;4.7) (IR) | Publications | |||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 4±(3.5;4.0) (IR) | 54±(44;73) (IR) | 703 | (0-24h) | 3,2±(2.6;7.2) (IR) | Publications | |||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 4±(4.0;6.0) (IR) | 35±(26;73) (IR) | 511 | (0-24h) | 3,9±(3.0;8.4) (IR) | Publications | |||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 4,3±0,3 (SEM) | 46±3 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 4,1±1,1 (SEM) | 14,7±2,2 (SEM) | 76,5 | (0-24h) | 1,07 | 2.2±0,39 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 4,9±0,6 (SEM) | 18,5±2,4 (SEM) | 131,8 | (0-24h) | 0,56 | 3.46µmol(0-24h)±0,51 (SEM) (3.46µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 4,8±1,1 (SEM) | 14,4±2,5 (SEM) | 110,5 | (0-24h) | 0,66 | 1.95µmol(0-24h)±0,36 (SEM) (1.95µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 4 g 'Green Blend' instant Coffee | food | 36 | 882,00 µmol | Single | 4,04 | 35.6µmol(0-36h)±19,2 (SD) (35.6µmol(0-36h)) | Publications | |||||||||
| Coffee Chlorogenic acids | Ferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | Tablets | extract | 11 | Healthy; 9 F; 2 M; Age=28±6 y; BMI=21.8±1.6 kg/m2 | 933,00 µmol | Multiple | 4 weeks (3 doses daily) | 1,14 | 10.6µmol(0-24h)±1,6 (SEM) (10.6µmol(0-24h)) | Publications |