Intervention Studies for the metabolite Coumaric acid-4'-O-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Coumaric acid-4'-O-glucuronide | Human | Plasma; Urine | Host metabolism | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 0,5±0,1 (SD) | 0,005±0,002 (SD) | 0,003 | (0-12h) | 0,03 | 0.23µmol(0-24h)±0,06 (SD) (0.23µmol(0-24h)) | Publications | ||||
| Coffee Chlorogenic acids | Coumaric acid-4'-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 778,43 µmol | Single | 3 | 0,96±0,28 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Coumaric acid-4'-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 214,15 µmol | Single | 3 | 1,13±0,31 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Coumaric acid-4'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 0,01 | 0.11µmol(0-24h)±0,04 (SD) (0.11µmol(0-24h)) | Publications |