Intervention Studies for the metabolite Isoferulic acid-3'-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 778,43 µmol | Single | 1 | 9,62±0,99 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 214,15 µmol | Single | 1 | 7,73±0,49 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Plasma | Host metabolism | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 1 | 0,018±0,007 (SD) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 4,4±1,1 (SEM) | 1,1±0,2 (SEM) | 5,5 | (0-24h) | 0,19 | 0.39±0,07 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 5,5±1,1 (SEM) | 1,4±0,1 (SEM) | 9 | (0-24h) | 0,20 | 1.22µmol(0-24h)±0,17 (SEM) (1.22µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 3,3±0,5 (SEM) | 1,3±0,2 (SEM) | 7 | (0-24h) | 0,24 | 0.72µmol(0-24h)±0,14 (SEM) (0.72µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 0,22 | 1.7µmol(0-24h)±0,2 (SD) (1.7µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 0,10 | 0.4µmol(0--24h)±0,1 (SEM) (0.4µmol(0--24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 0,10 | 0.3µmol(0-24h)±(02.;0.4) (IR) (0.3µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 0,10 | 0.4µmol(0-24h)±(0.3;0.7) (IR) (0.4µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Isoferulic acid-3'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 0,10 | 0.4µmol(0-24h)±(0;0.5) (IR) (0.4µmol(0-24h)) | Publications |