Intervention Studies for the metabolite Caffeic acid 3'-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Plasma | Host metabolism | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 1±(0.5;1.3) (IR) | 90 (IR) | 227 | (0-24h) | 1,2±(0.8;3.4) (IR) | Publications | |||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Plasma | Host metabolism | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 1±(0.8;1.0) (IR) | 89±(67;162) (IR) | 359 | (0-24h) | 1,2±(0.7;1.4) (IR) | Publications | |||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Plasma | Host metabolism | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 0,5±(0.5;1.0) (IR) | 79±(60;107) (IR) | 184 | (0-24h) | 0,9±(0.7;1.1) (IR) | Publications | |||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 214,15 µmol | Single | 1 | 1,11±0,54 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 778,43 µmol | Single | 1 | 68,75±6,23 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Plasma | Host metabolism | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 0,45 | 57 | 6927 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Plasma | Host metabolism | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,88 | 46 | 2054 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Plasma | Host metabolism | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,43 | 50 | 4440 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Plasma; Urine | Host metabolism | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 1±0,2 (SEM) | 92±11 (SEM) | 306 | (0-24h) | 1,9±0,4 (SEM) | 1,55 | 6.4µmol(4-24h)±0,8 (SEM) (6.4µmol(4-24h)) | Publications | |||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 0,34 | 2.6µmol(0-24h)±0,5 (SD) (2.6µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 0,07 | 0.15µmol(0-24h)±0,02 (SEM) (0.15µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 0,07 | 0.42µmol(0-24h)±0,05 (SEM) (0.42µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Caffeic acid 3'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 0,12 | 0.35µmol(0-24h)±0,04 (SEM) (0.35µmol(0-24h)) | Publications |