Intervention Studies for the metabolite caffeic acid-4'-O-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | caffeic acid-4'-O-glucuronide | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 778,43 µmol | Single | 1 | 2,8±0,42 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | caffeic acid-4'-O-glucuronide | Human | Plasma | Host metabolism | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 214,15 µmol | Single | 1 | 2,53±0,47 (SEM) | Publications | ||||||||
| Coffee Chlorogenic acids | caffeic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 3,3±1,2 (SEM) | 2±0,3 (SEM) | 12,7 | (0-24h) | 0,06 | 0.13±0,01 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | caffeic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 5,5±0,4 (SEM) | 2,7±0,3 (SEM) | 20,7 | (0-24h) | 0,05 | 0.29µmol(0-24h)±0,03 (SEM) (0.29µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | caffeic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 3,4±0,6 (SEM) | 1,9±0,4 (SEM) | 12 | (0-24h) | 0,04 | 0.13µmol(0-24h)±0,02 (SEM) (0.13µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | caffeic acid-4'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | Tablets | extract | 11 | Healthy; 9 F; 2 M; Age=28±6 y; BMI=21.8±1.6 kg/m2 | 933,00 µmol | Multiple | 4 weeks (3 doses daily) | 0,04 | 0.4µmol(0-24h)±0,1 (SEM) (0.4µmol(0-24h)) | Publications |