Intervention Studies for the metabolite Dihydrocaffeic acid-4'-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Dihydrocaffeic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 6 ± 0.1±0,1 (SD) | 0,26±0,09 (SD) | 1,1 | (0-12h) | 0,08 | 0.6µmol(0-24)±0,1 (SD) | Publications | ||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 0,08 | 0.17µmol(0-24h)±0,05 (SEM) (0.17µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 0,11 | 0.67µmol(0-24h)±0,14 (SEM) (0.67µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 0,14 | 0.41µmol(0-24h)±0,1 (SEM) (0.41µmol(0-24h)) | Publications |