Intervention Studies for the metabolite Protocatechuic acid-3-O-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Protocatechuic acid-3-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 1,8±0,5 (SEM) | 1,6±0,3 (SEM) | 6,4 | (0-24h) | Publications | |||||
| Coffee Chlorogenic acids | Protocatechuic acid-3-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 4,8±0,7 (SEM) | 2,3±0,3 (SEM) | 12,8 | (0-24h) | Publications | |||||
| Coffee Chlorogenic acids | Protocatechuic acid-3-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 4±0,6 (SEM) | 2,2±0,3 (SEM) | 13,1 | (0-24h) | Publications |