Intervention Studies for the metabolite Vanillic acid 4-O-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Vanillic acid 4-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 6,1±1,4 (SEM) | 13±1,8 (SEM) | 102,8 | (0-24h) | 1,41 | 2.88µmol(0-24h)±0,71 (SEM) (2.88µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Vanillic acid 4-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 6,9±1,4 (SEM) | 15,7±2,4 (SEM) | 142,5 | (0-24h) | 0,58 | 3.57µmol(0-24h)±0,85 (SEM) (3.57µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Vanillic acid 4-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 6,3±0,4 (SEM) | 52,5±5,4 (SEM) | 362,6 | (0-24h) | 1,88 | 5.57µmol(0-24h)±0,59 (SEM) (5.57µmol(0-24h)) | Publications |