Intervention Studies for the metabolite Dihydroisoferulic acid-3'-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Dihydroisoferulic acid-3'-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,45 | 48 | 12239 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroisoferulic acid-3'-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 10,20 | 42 | 11544 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroisoferulic acid-3'-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,85 | 40 | 9901 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroisoferulic acid-3'-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 7 ± 1±1 (SD) | 0,02±0,01 (SD) | 0,1 | (0-12h) | 0,53 | 4µmol(0-24h)±1 (SD) (4µmol(0-24h)) | Publications | ||||
| Coffee Chlorogenic acids | Dihydroisoferulic acid-3'-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 8±1,3 (SEM) | 42,2±7 (SEM) | 413,2 | (0-24h) | 0,73 | 1.5±0,26 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroisoferulic acid-3'-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 9,1±1,4 (SEM) | 39,1±5,3 (SEM) | 469,6 | (0-24h) | 0,47 | 2.9µmol(0-24h)±0,5 (SEM) (2.9µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroisoferulic acid-3'-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 7,5±0,9 (SEM) | 33,6±5,6 (SEM) | 356,2 | (0-24h) | 0,48 | 1.41µmol(0-24h)±0,26 (SEM) (1.41µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroisoferulic acid-3'-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 0,61 | 2.5µmol(0-24h)±0,4 (SEM) (2.5µmol(0-24h)) | Publications |