Intervention Studies for the metabolite Dihydroferulic acid-4'-O-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 7,75 | 120 | 33194 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 9,12 | 117 | 33671 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,28 | 111 | 30455 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 0,074±0,055 (SD) | Publications | |||||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Plasma | Host-gut microbiota co-metabolite | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 0,099 | Publications | |||||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 6 ± 1±1 (SD) | 0,06±0,04 (SD) | 0,3 | (0-12h) | 1,05 | 8µmol(0-24h)±2 (SD) (8µmol(0-24h)) | Publications | ||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 2,50 | 5.12µmol(0-24h)±0,6 (SEM) (5.12µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 1,05 | 6.43µmol(0-24h)±1,02 (SEM) (6.43µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 1,40 | 4.13µmol(0-24h)±0,47 (SEM) (4.13µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 2,04 | 8.4µmol(0-24h)±1,9 (SEM) (8.4µmol(0-24h)) | Publications |