Intervention Studies for the metabolite Dihydroferulic acid-4'-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 7,42 | 112 | 26797 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,67 | 107 | 29088 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,00 | 95 | 22703 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 0,094±0,073 (SD) | Publications | |||||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 5,6±0,7 (SD) | 0,09±0,05 (SD) | 0,4 | (0-12h) | 1,71 | 13µmol(0-24h)±3 (SD) (13µmol(0-24h)) | Publications | ||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 4,8±0,5 (SEM) | 145±53 (SEM) | 1193 | (0-24h) | 4,7±0,8 (SEM) | 3,01 | 12.4µmol±3,4 (0-24h) (SEM) ((0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 6±(4.0;6.0) (IR) | 88±(44;166) (IR) | 834 | (0-24h) | 3,3±(2.5;7.2) (IR) | 2,80 | 11.4µmol(0-24h)±(54.;13.9) (IR) (11.4µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 6±(5.0;8.0) (IR) | 98±(46;172) (IR) | 1189 | (0-24h) | 3,5±(2.6;5.3) (IR) | 2,00 | 12.4µmol(0-24h)±(3.4;22.5) (IR) (12.4µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 6±(6.0;6.0) (IR) | 117±(80;327) (IR) | 1043 | (0-24h) | 2,9±(2.6;4.1) (IR) | 2,20 | 17.5µmol(0-24h)±(6;25.8) (IR) (17.5µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 0,59 | 1.21µmol(0-24h)±0,18 (SEM) (1.21µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 0,32 | 1.96µmol(0-24h)±0,38 (SEM) (1.96µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 0,28 | 0.83µmol(0-24h)±0,14 (SEM) (0.83µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Dihydroferulic acid-4'-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 4 g 'Green Blend' instant Coffee | food | 36 | 882,00 µmol | Single | 2,80 | 24.7µmol(0-36h)±17,9 (SD) (24.7µmol(0-36h)) | Publications |