Intervention Studies for the metabolite 3-Phenylpropionic acid-4'-O-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | 3-Phenylpropionic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 6,4±1,2 (SEM) | 47,8±8 (SEM) | 409 | (0-24h) | 1,07 | 2.2µmol(0-24h)±0,34 (SEM) (2.2µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | 3-Phenylpropionic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 5,2±1,2 (SEM) | 53,5±7,9 (SEM) | 560 | (0-24h) | 0,66 | 4.08µmol(0-24h)±0,62 (SEM) (4.08µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | 3-Phenylpropionic acid-4'-O-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 7,2±1,6 (SEM) | 44±6,5 (SEM) | 483,6 | (0-24h) | 1,01 | 3µmol(0-24h)±0,42 (SEM) (3µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | 3-Phenylpropionic acid-4'-O-glucuronide | Human | Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 0,01 | 0.09µmol(0-24h)±0,02 (SD) (0.09µmol(0-24h)) | Publications |