Intervention Studies for the metabolite Dihydrocaffeic acid-3-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 7,5±1,3 (SEM) | 31,9±8 (SEM) | 200,1 | (0-24h) | Publications | |||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 5,9±0,7 (SEM) | 25,8±6,5 (SEM) | 157,5 | (0-24h) | Publications | |||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 6±1 (SEM) | 43,5±13,7 (SEM) | 294,2 | (0-24h) | Publications | |||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 7,58 | 240 | 74525 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,95 | 149 | 19917 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8,48 | 169 | 48627 | (0-15h) | Publications | ||||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 4,8±0,6 (SEM) | 325±99 (SEM) | 2648 | (0-24h) | 3,1±0,3 (SEM) | 9,00 | 37.1µmol(0-24h)±8,2 (SEM) (37.1µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 6±(4.0;6.0) (IR) | 220±(107;429) (IR) | 1787 | (0-24h) | 2,7±(2.3;3.9) (IR) | 8,70 | 35.7µmol(0-24h)±(163.;43.0) (IR) (35.7µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 6±(6.0;7.0) (IR) | 465±(174;772) (IR) | 3768 | (0-24h) | 2,4±(2.0;3.9) (IR) | 7,50 | 47.4µmol(0-24h)±(27.8;71.2) (IR) (47.4µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 6±(6.0;6.0) (IR) | 409±(318;678) (IR) | 3839 | (0-24h) | 2,1±(1.9;2.2) (IR) | 6,00 | 47.9µmol(0-24h)±(36.6;89.9) (IR) (47.9µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 4,08 | 31µmol(0-24h)±8 (SD) (31µmol(0-24h)) | Publications | ||||||||
| Coffee Chlorogenic acids | Dihydrocaffeic acid-3-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 4 g 'Green Blend' instant Coffee | food | 36 | 882,00 µmol | Single | 7,74 | 68.3µmol(0-36h)±54,8 (SD) (68.3µmol(0-36h)) | Publications |