Intervention Studies for the metabolite Methylpyrogallol-O-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Methylpyrogallol-O-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 4±1,1 (SEM) | 56,5±13,6 (SEM) | 323,3 | (0-24h) | 0,78 | 1.6µmol(0-24h)±0,37 (SEM) (1.6µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Methylpyrogallol-O-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 5±0,7 (SEM) | 65,9±11,4 (SEM) | 596,8 | (0-24h) | 0,43 | 2.67µmol(0-24h)±0,74 (SEM) (2.67µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Methylpyrogallol-O-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 5,8±1,1 (SEM) | 61,3±9,5 (SEM) | 510 | (0-24h) | 0,46 | 1.35µmol(0-24h)±0,24 (SEM) (1.35µmol(0-24h)) | Publications |