Intervention Studies for the metabolite 3-(phenyl)propionic acid-3′-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | 3-(phenyl)propionic acid-3′-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 8806 | (0-15h) | Publications | ||||||||
| Coffee Chlorogenic acids | 3-(phenyl)propionic acid-3′-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 7935 | (0-15h) | Publications | ||||||||
| Coffee Chlorogenic acids | 3-(phenyl)propionic acid-3′-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 2834 | (0-15h) | Publications | ||||||||
| Coffee Chlorogenic acids | 3-(phenyl)propionic acid-3′-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 3±0,7 (SEM) | 19,2±5,8 (SEM) | 71,5 | (0-24h) | 0,56 | 1.15µmol(0-24h)±0,12 (SEM) (1.15µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | 3-(phenyl)propionic acid-3′-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 5,6±1,1 (SEM) | 18,6±3,1 (SEM) | 124,1 | (0-24h) | 0,28 | 1.7µmol(0-24h)±0,28 (SEM) (1.7µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | 3-(phenyl)propionic acid-3′-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 5,5±1,1 (SEM) | 15,7±2,5 (SEM) | 102,7 | (0-24h) | 0,40 | 1.19µmol(0-24h)±0,16 (SEM) (1.19µmol(0-24h)) | Publications |