Intervention Studies for the metabolite Trimethoxycinnamic acid-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Trimethoxycinnamic acid-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 1,6±0,5 (SEM) | 3,5±0,7 (SEM) | 6,8 | (0-24h) | 0,61 | 1.25±0,13 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Trimethoxycinnamic acid-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 3,2±0,6 (SEM) | 4,3±0,7 (SEM) | 18,7 | (0-24h) | 0,55 | 3.35µmol(0-24h)±0,3 (SEM) (3.35µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Trimethoxycinnamic acid-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 3,2±1,1 (SEM) | 3,7±1 (SEM) | 9,7 | (0-24h) | 0,47 | 1.4µmol(0-24h)±0,12 (SEM) (1.4µmol(0-24h)) | Publications |