Intervention Studies for the metabolite Coumaroylquinic lactone-glucuronide with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Coumaroylquinic lactone-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 4,4±0,8 (SEM) | 85,8±12,5 (SEM) | 739,4 | (0-24h) | 8,20 | 16.81±2,75 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Coumaroylquinic lactone-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 6±0,6 (SEM) | 104,8±11 (SEM) | 1265 | (0-24h) | 5,81 | 35.72µmol(0-24h)±6,45 (SEM) (35.72µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Coumaroylquinic lactone-glucuronide | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 6,5±0,4 (SEM) | 107,2±10,7 (SEM) | 1284 | (0-24h) | 10,89 | 32.24µmol(0-24h)±5,44 (SEM) (32.24µmol(0-24h)) | Publications |