Intervention Studies for the metabolite Catechol-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Catechol-sulfate | Human | Plasma | Host-gut microbiota co-metabolite | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 0,75 | 2,469±0,57 (SD) | Publications | ||||||||
| Coffee Chlorogenic acids | Catechol-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 3,9±1,1 (SEM) | 365,4±82,2 (SEM) | 1956,9 | (0-24h) | 45,02 | 92.25µmol(0-24h)±12,92 (SEM) (92.25µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Catechol-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 5,2±0,7 (SEM) | 355,3±45,5 (SEM) | 2989 | (0-24h) | 22,85 | 140.42µmol(0-24h)±13,53 (SEM) (140.42µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Catechol-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 5,2±0,7 (SEM) | 469,7±69,4 (SEM) | 3764,9 | (0-24h) | 50,10 | 148.3µmol(0-24h)±16,4 (SEM) (148.3µmol(0-24h)) | Publications |