Intervention Studies for the metabolite Methylcatechol-sulfate with food phytochemical Coffee Chlorogenic acids
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coffee Chlorogenic acids | Methylcatechol-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 1,6±0,4 (SEM) | 52±7,5 (SEM) | 191,6 | (0-24h) | 2,47 | 5.07µmol(0-24h)±0,56 (SEM) (5.07µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Methylcatechol-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 4,9±0,6 (SEM) | 109,6±21,3 (SEM) | 646,4 | (0-24h) | 1,49 | 9.18µmol(0-24h)±1,23 (SEM) (9.18µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Methylcatechol-sulfate | Human | Plasma; Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 5±0,6 (SEM) | 82,5±15,7 (SEM) | 511,7 | (0-24h) | 2,89 | 8.55µmol(0-24h)±0,97 (SEM) (8.55µmol(0-24h)) | Publications | |||
| Coffee Chlorogenic acids | Methylcatechol-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 1,78 | 3.64µmol(0-24h)±0,61 (SEM) (3.64µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Methylcatechol-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 1,51 | 9.27µmol(0-24h)±1,64 (SEM) (9.27µmol(0-24h)) | Publications | |||||||
| Coffee Chlorogenic acids | Methylcatechol-sulfate | Human | Urine | Host-gut microbiota co-metabolite | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 1,90 | 5.63µmol(0-24h)±0,84 (SEM) (5.63µmol(0-24h)) | Publications |