Intervention Studies for the metabolite 5-O-Caffeoylquinic acid with food phytochemical 5-O-Caffeoylquinic acid
| Food Phytochemical | Metabolite | Species | Biofluids | Origin | Dietary Source Description | Dietary Source Classification | Total Number of Subjects | Description of Population | Ingested Amount | Single/Multiple Dose | Duration of the Study | Tmax (h) | Cmax (nM) | AUC (nM/h) | Time covered by AUC (h) | t 1/2 (h) | % of 24h Urinary Excretion | Excreted Amount & Time Interval | Publications | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 1±(0.9;1.1) (IR) | 5±(5.0;7.0) (IR) | 5,2 | (0-24h) | 0,3±(0.2;1.0) (IR) | Publications | |||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 635,00 µmol | Single | 0,5±(0.5;1.0) (IR) | 10±(6.6;13) (IR) | 7,5 | (0-24h) | 0,2±(0.2;0.3) (IR) | Publications | |||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 200 mL of instant coffee beverage | food | 11 | healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 795,00 µmol | Single | 1±(0.5;1.0) (IR) | 11±(5.9;13) (IR) | 14,7 | (0-24h) | 0,6±(0.4;0.6) (IR) | Publications | |||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 778,43 µmol | Single | 1 | 19,02±1,57 (SEM) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 3.6 g of ground coffee + 50 mL water | food | 15 | Healthy; Age=26.3 ± 1.6 y; BMI=23.5 ± 0.5 kg/m2 | 214,15 µmol | Single | 1 | 9,86±0,9 (SEM) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 200 mL of coffee (3.4 g of instant powder) | food | 11 | Healthy; 8 M; 3 F; Age=19-35 y; BMI=24.3±2.3 kg/m2 | 412,00 µmol | Single | 1±0,2 (SEM) | 2,2±1 (SEM) | 4,1 | (0-24h) | 0,3±0,3 (SEM) | Publications | |||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 200 mL of instant coffee beverage | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 0,50 | 19 | 1232 | (0-15h) | Publications | ||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 200 mL of coffee + 2 bread rolls + honey | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,18 | 14 | 720 | (0-15h) | Publications | ||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 350 mL of coffee (18.66 g of coffee) | food | 13 | Healthy; 6 F (Age=24–28 y); 7 M (Age=27–30 y) | 519,07 µmol | Single | 0,75 | 0,036±0,013 (SD) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 200 mL of coffee + 1 bread roll + peanut butter | food | 14 | Healthy; 7 M; 7 F; Age=29.36±8.06 y; BMI=22.95±1.72 kg/m2; Caucasians | 48,03 µmol | Single | 1,08 | 18 | 1515 | (0-15h) | Publications | ||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 450 mL of cranberry drink | food | 10 | Healthy; Age=18-35 y | 641,05 µmol | Single | 4,9±0,9 (SEM) | 4±2 (SEM) | 37 | (0-24h) | Publications | ||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 2.4 g of Shuanghua Baihe tablets | extract | 12 | Healthy; 6 M; 6 F; Chinese | 10,28 µmol | Single | 1±0,5 (SD) | 0,7638±0,542 (SD) | 1,135 | (0-6h) | 1,3±0,6 (SD) | Publications | |||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 2.4 g of Shuanghua Baihe tablets | extract | 12 | Healthy; 6 M; 6 F; Chinese | 10,28 µmol | Multiple | 3 daily doses (5 days) | 1,1±0,5 (SD) | 0,6637±0,5833 (SD) | 1,782 | (0-6h) | 1,4±0,7 (SD) | Publications | ||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 450 mL of cranberry drink | food | 10 | Healthy; Age=18-35 y | 1233,51 µmol | Single | 6,8±2,3 (SEM) | 5±2 (SEM) | 40 | (0-24h) | Publications | ||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 450 mL of cranberry drink | food | 10 | Healthy; Age=18-35 y | 1940,38 µmol | Single | 8,3±2,2 (SEM) | 11±5 (SEM) | 107 | (0-24h) | Publications | ||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 450 mL of cranberry drink | food | 10 | Healthy; Age=18-35 y | 2404,32 µmol | Single | 11±3,4 (SEM) | 9±4 (SEM) | 63 | (0-24h) | Publications | ||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma | Unchanged | 450 mL of cranberry drink | food | 10 | Healthy; Age=18-35 y | 2993,64 µmol | Single | 8,3±3,1 (SEM) | 5±2 (SEM) | 55 | (0-24h) | Publications | ||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma; Urine | Unchanged | 250 mL of coffee (3.5 g of green-roasted coffee) | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 760.6 μmol | Single | 1,2 | 0,03 | 0.21µmol(0-24h)±0,07 (SD) (0.21µmol(0-24h)) | Publications | |||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma; Urine | Unchanged | 1 cup of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 204,90 µmol | Multiple | 1 month (1 daily dose) | 1,7±0,4 (SEM) | 3,8±0,3 (SEM) | 13,6 | (0-24h) | 0,14 | 0.29±0,05 µmol(0-24h) (SEM) (µmol(0-24h)) | Publications | |||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma; Urine | Unchanged | 3 cups of coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 614,60 µmol | Multiple | 1 month (3 dose daily) | 4,1±0,6 (SEM) | 4,8±0,5 (SEM) | 35,7 | (0-24h) | 0,10 | 0.61µmol(0-24h)±0,08 (SEM) (0.61µmol(0-24h)) | Publications | |||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma; Urine | Unchanged | 1 cup of coffee + 2 cocoa products containing coffee | food | 21 | Healthy; 11 F; 10 M; Age=22.9 ± 0.5 y; BMI: 22.3 ± 1.7 kg/m2 | 296,00 µmol | Multiple | 1 month (2 dose daily) | 3,1±1,1 (SEM) | 3,9±0,6 (SEM) | 19,9 | (0-24h) | 0,09 | 0.28µmol(0-24h)±0,03 (SEM) (0.28µmol(0-24h)) | Publications | |||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Plasma; Urine | Unchanged | 200 g of sous-vide artichokes | food | 8 | Healthy; 5 F; 3 M; Age=26.4±2.8; BMI: 22.8±2.5 kg/m2 | 5714,60 µmol | Single | 78 | 414 | (0-24h) | 0,04 | 2.2µmol(0-24h) (2.2µmol(0-24h)) | Publications | |||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Serum | Unchanged | 480 mg of green coffee bean extract | extract | 15 | Healthy; M | 123,34 µmol | Single | 1,5 | 7,2±3,66 (SD) | 15,7 | (0-4h) | Publications | ||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 4.91 g of yerba mate in 250 mL water | food | 12 | Healthy; 7 M (Age=27.86±3.48 y; BMI=23.42±2.52 kg/m2); 5 F (Age=28.88±3.56 y; BMI=22.43±3.33 kg/m2) | 1118,00 µmol | Single | 0,01 | 0.111µmol(0-24h)±0,029 (SD) (0.111µmol(0-24h)) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 500 g of tomato | food | 40 | Healthy; 19 M; 21 F; Age=28±11 y; BMI=23.3±3.8 Kg/m2 | 20,38 µmol | Single | 0,98 | 0.2µmol(0-24h) (0.2µmol(0-24h)) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 250 g of tomato sauce | food | 40 | Healthy; 19 M; 21 F; Age=28±11 y; BMI=23.3±3.8 Kg/m2 | 22,92 µmol | Single | 0,65 | 0.2µmol(0-24h) (0.2µmol(0-24h)) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 250 g of tomato sauce + refined olive oil (5%) | food | 40 | Healthy; 19 M; 21 F; Age=28±11 y; BMI=23.3±3.8 Kg/m2 | 23,38 µmol | Single | 0,77 | 0.2µmol(0-24h) (0.2µmol(0-24h)) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 500 g of raw tomatoes | food | 8 | Healthy; 4 F; Age=27-46 y; BMI= 23 ± 0.93 kg/m2 | 14,15 µmol | Single | 0,47 | 0.07µmol(0-24h) (0.07µmol(0-24h)) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 250 g of raw tomato sauce | food | 8 | Healthy; 4 F; Age=27-46 y; BMI= 23 ± 0.93 kg/m2 | 19,18 µmol | Single | 0,33 | 0.06µmol(0-24h) (0.06µmol(0-24h)) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 250 g of refined olive oil-enriched tomato sauce | food | 8 | Healthy; 4 F; Age=27-46 y; BMI= 23 ± 0.93 kg/m2 | 20,06 µmol | Single | 0,10 | 0.02µmol(0-24h) (0.02µmol(0-24h)) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 450 mL of cranberry juice | food | 10 | Healthy; M; Age=18-35 y | 1233,51 µmol | Single | 0,00 | 19µg(0-24h)±9 (SEM) (19µg(0-24h)) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 9 g of cranberry powder + 500 mL water | food | 45 | Healthy; M; Age=18-45 y | 951,00 µmol | Single | 0,06 | 0.6µmol(0-24h)±0,1 (SEM) (0.6µmol(0-24h)) | Publications | ||||||||
| 5-O-Caffeoylquinic acid | 5-O-Caffeoylquinic acid | Human | Urine | Unchanged | 9 g of cranberry powder + 500 mL water | food | 45 | Healthy; M; Age=18-45 y | 951,00 µmol | Multiple | 1 month (1 dose daily) | 0,04 | 0.4µmol(0-24h)±0,1 (SEM) (0.4µmol(0-24h)) | Publications |